Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages.

Animals Autophagy / drug effects Colitis / drug therapy Crohn Disease / drug therapy Cytokines / metabolism Dextran Sulfate / pharmacology Epithelial Cells / drug effects Female Herbal Medicine / methods Inflammation / drug therapy Inflammatory Bowel Diseases / drug therapy Intestines / drug effects Macrophages / drug effects Mice Mice, Inbred C57BL Microfilament Proteins / metabolism Myeloid Cells / drug effects Phytotherapy / methods Plant Preparations / pharmacology Plants, Medicinal / chemistry Sanguisorba / chemistry

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
19 06 2020
Historique:
received: 05 12 2019
accepted: 04 05 2020
entrez: 21 6 2020
pubmed: 21 6 2020
medline: 15 12 2020
Statut: epublish

Résumé

Disturbed activation of autophagy is implicated in the pathogenesis of inflammatory bowel disease. Accordingly, several autophagy-related genes have been identified as Crohn's disease susceptibility genes. We screened the autophagy activators from a library including 3,922 natural extracts using a high-throughput assay system. The extracts identified as autophagy activators were administered to mice with 2% dextran sodium sulfate (DSS). Among the autophagy inducers, Sanguisorba officinalis L. (SO) suppressed DSS-induced colitis. To identify the mechanism by which SO ameliorates colitis, epithelial cell and innate myeloid cells-specific Atg7-deficient mice (Villin-cre; Atg7

Identifiants

DOI: 10.1038/s41598-020-65306-4 PMID: 32561763 PMC: PMC7305163
pubmed: 32561763
doi: 10.1038/s41598-020-65306-4
pii: 10.1038/s41598-020-65306-4
pmc: PMC7305163
doi:

Substances chimiques

Cytokines 0
Microfilament Proteins 0
Plant Preparations 0
villin 0
Dextran Sulfate 9042-14-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9972

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Auteurs

Asuka Yasueda (A)

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Hisako Kayama (H)

Laboratory of Immune Regulation, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Institute for Advanced Co-Creation Studies, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Michiko Murohashi (M)

Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Junichi Nishimura (J)

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Koji Wakame (K)

Department pharmacology, Hokkaido University of Science, 15-4-1, Maeda shichi-jyo, Teine, Sapporo City, Hokkaido, 006-8590, Japan.

Ken-Ichi Komatsu (KI)

Department pharmacology, Hokkaido University of Science, 15-4-1, Maeda shichi-jyo, Teine, Sapporo City, Hokkaido, 006-8590, Japan.

Takayuki Ogino (T)

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Norikatsu Miyoshi (N)

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Hidekazu Takahashi (H)

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Mamoru Uemura (M)

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Chu Matsuda (C)

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Toru Kitagawa (T)

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Kiyoshi Takeda (K)

Laboratory of Immune Regulation, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, 1-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Toshinori Ito (T)

Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-6-107, Morinomiya, Jyoto-ku, Osaka City, Osaka, 536-0025, Japan.

Yuichiro Doki (Y)

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Hidetoshi Eguchi (H)

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Shigeomi Shimizu (S)

Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Tsunekazu Mizushima (T)

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. tmizushima@gesurg.med.osaka-u.ac.jp.
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, 1-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. tmizushima@gesurg.med.osaka-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Maladie de Crohn › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Dextrane › Sulfate dextran › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Cellules › Cellules épithéliales › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Professions de santé › Pharmacologie › Science des plantes médicinales › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Thérapeutique › Thérapies complémentaires › Phytothérapie › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Préparations à base de plantes › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Eucaryotes › Plantes › Plantes médicinales › Sanguisorba officinalis L. derived from herbal...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rosanae › Rosales › Rosaceae › Sanguisorba › Sanguisorba officinalis L. derived from herbal...