Prediction of Ubiquitin Ligase Nrdp1-Associated Proteins in Glioma Database.
Bioinformatics
GSEA (gene set enrichment analysis)
Genomics
Glioma
Nrdp1 (neuregulin receptor degradation protein-1)
Ubiquitination
Journal
Cell biochemistry and biophysics
ISSN: 1559-0283
Titre abrégé: Cell Biochem Biophys
Pays: United States
ID NLM: 9701934
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
13
06
2019
accepted:
09
06
2020
pubmed:
21
6
2020
medline:
18
2
2021
entrez:
21
6
2020
Statut:
ppublish
Résumé
The ubiquitin proteasome pathway is conserved from yeast to mammals and is necessary for the targeted degradation of most short-lived proteins in eukaryotic cells. Its protein substrates include cell cycle regulatory proteins and proteins that are not properly folded in the endoplasmic reticulum. Owing to the ubiquity of its protein substrates, ubiquitination regulates a variety of cellular activities, including cell proliferation, apoptosis, autophagy, endocytosis, DNA damage repair, and immune response. With new genomic data continuously being obtained, ubiquitination through genomic data analysis will be an effective method. We obtained 83 overlapping genes from four glioma databases, which differed from ubiquitin ligase Nrdp1 expression, including 36 downregulated and 47 upregulated genes. The KEGG pathways, molecular functions, cellular components, and biological processes potentially associated with Nrdp1 were obtained using GSEA and Cytoscape. In human gliomas, differences in the expression of Nrdp1 were identified between nontumor brain tissue and different glioma tissues, but no difference in expression was found between low‑grade glioma (LGG) and anaplastic glioma (AG). In survival analysis, we found no significant association between Nrdp1 expression level and patient prognosis.
Identifiants
pubmed: 32562142
doi: 10.1007/s12013-020-00926-1
pii: 10.1007/s12013-020-00926-1
doi:
Substances chimiques
RNF41 protein, human
EC 2.3.2.27
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
301-308Subventions
Organisme : Jiangsu Provincial Health Department
ID : grant no. YG201514
Organisme : Xuzhou Medical University
ID : grant no. 2018KJ09
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