Heparin affects the induction of regulatory T cells independent of anti-coagulant activity and suppresses allogeneic immune responses.
IL-2
acute GVHD mice
conventional T cell
heparin
regulatory T cells
Journal
Clinical and experimental immunology
ISSN: 1365-2249
Titre abrégé: Clin Exp Immunol
Pays: England
ID NLM: 0057202
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
14
01
2020
revised:
11
06
2020
accepted:
16
06
2020
pubmed:
21
6
2020
medline:
20
1
2021
entrez:
21
6
2020
Statut:
ppublish
Résumé
Heparin is a widely used anti-coagulant that enhances anti-thrombin (AT) activity. However, heparin also suppresses immune and inflammatory responses in various rodent models and clinical trials, respectively. The mechanism by which heparin suppresses immune responses is unclear. The effect of heparin on regulatory T cells (T
Identifiants
pubmed: 32562271
doi: 10.1111/cei.13480
pmc: PMC7488123
doi:
Substances chimiques
Anticoagulants
0
Fibrinolytic Agents
0
Heparin
9005-49-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
119-135Informations de copyright
© 2020 British Society for Immunology.
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