Susceptibility to auditory closed-loop stimulation of sleep slow oscillations changes with age.
ageing
auditory closed-loop stimulation
memory
sleep
sleep spindles
slow oscillations
Journal
Sleep
ISSN: 1550-9109
Titre abrégé: Sleep
Pays: United States
ID NLM: 7809084
Informations de publication
Date de publication:
14 12 2020
14 12 2020
Historique:
received:
28
01
2020
revised:
10
05
2020
pubmed:
21
6
2020
medline:
15
4
2021
entrez:
21
6
2020
Statut:
ppublish
Résumé
Cortical slow oscillations (SOs) and thalamocortical sleep spindles hallmark slow wave sleep and facilitate memory consolidation, both of which are reduced with age. Experiments utilizing auditory closed-loop stimulation to enhance these oscillations showed great potential in young and older subjects. However, the magnitude of responses has yet to be compared between these age groups. We examined the possibility of enhancing SOs and performance on different memory tasks in a healthy middle-aged population using this stimulation and contrast effects to younger adults. In a within-subject design, 17 subjects (55.7 ± 1.0 years) received auditory stimulation in synchrony with SO up-states, which was compared to a no-stimulation sham condition. Overnight memory consolidation was assessed for declarative word-pairs and procedural finger-tapping skill. Post-sleep encoding capabilities were tested with a picture recognition task. Electrophysiological effects of stimulation were compared to a previous younger cohort (n = 11, 24.2 ± 0.9 years). Overnight retention and post-sleep encoding performance of the older cohort revealed no beneficial effect of stimulation, which contrasts with the enhancing effect the same stimulation protocol had in our younger cohort. Auditory stimulation prolonged endogenous SO trains and induced sleep spindles phase-locked to SO up-states in the older population. However, responses were markedly reduced compared to younger subjects. Additionally, the temporal dynamics of stimulation effects on SOs and spindles differed between age groups. Our findings suggest that the susceptibility to auditory stimulation during sleep drastically changes with age and reveal the difficulties of translating a functional protocol from younger to older populations.
Identifiants
pubmed: 32562487
pii: 5850478
doi: 10.1093/sleep/zsaa111
pmc: PMC7734479
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/J014478/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 105610/Z/14/Z
Pays : United Kingdom
Informations de copyright
© Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society.
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