Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development.

Animals Axons / metabolism Cell Movement / physiology Dopaminergic Neurons / cytology GABAergic Neurons / cytology Mice Mice, Transgenic Netrin-1 / metabolism Prosencephalon / metabolism Substantia Nigra / cytology
GABAergic neuron Netrin-1 development dopamine neuron fluorescent light sheet microscopy guidance cue intersectional genetics migration neuronal subtype substantia nigra

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
19 08 2020
Historique:
received: 18 12 2019
revised: 17 04 2020
accepted: 26 05 2020
pubmed: 21 6 2020
medline: 3 11 2020
entrez: 21 6 2020
Statut: ppublish

Résumé

The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviors and show select disease vulnerability, including in Parkinson's disease. Despite progress in identifying mDA neuron subtypes, how these neuronal subsets develop and organize into functional brain structures remains poorly understood. Here we generate and use an intersectional genetic platform, Pitx3-ITC, to dissect the mechanisms of substantia nigra (SN) development and implicate the guidance molecule Netrin-1 in the migration and positioning of mDA neuron subtypes in the SN. Unexpectedly, we show that Netrin-1, produced in the forebrain and provided to the midbrain through axon projections, instructs the migration of GABAergic neurons into the ventral SN. This migration is required to confine mDA neurons to the dorsal SN. These data demonstrate that neuron migration can be controlled by remotely produced and axon-derived secreted guidance cues, a principle that is likely to apply more generally.

Identifiants

DOI: 10.1016/j.neuron.2020.05.037 PMID: 32562661
pubmed: 32562661
pii: S0896-6273(20)30406-2
doi: 10.1016/j.neuron.2020.05.037
pii:
doi:

Substances chimiques

Netrin-1 158651-98-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

684-702.e9

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Auteurs

Sara Brignani (S)

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.

Divya D A Raj (DDA)

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.

Ewoud R E Schmidt (ERE)

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.

Özge Düdükcü (Ö)

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.

Youri Adolfs (Y)

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.

Anna A De Ruiter (AA)

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.

Mateja Rybiczka-Tesulov (M)

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.

Marieke G Verhagen (MG)

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.

Christiaan van der Meer (C)

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.

Mark H Broekhoven (MH)

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.

Juan A Moreno-Bravo (JA)

Institut de la Vision, Sorbonne Université, INSERM, CNRS, 17 Rue Moreau, 75012 Paris, France.

Laurens M Grossouw (LM)

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.

Emilie Dumontier (E)

Montreal Neurological Institute, 3801 University, Montréal, QC H3A 2B4, Canada.

Jean-François Cloutier (JF)

Montreal Neurological Institute, 3801 University, Montréal, QC H3A 2B4, Canada.

Alain Chédotal (A)

Institut de la Vision, Sorbonne Université, INSERM, CNRS, 17 Rue Moreau, 75012 Paris, France.

R Jeroen Pasterkamp (RJ)

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands. Electronic address: r.j.pasterkamp@umcutrecht.nl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Remotely Produced and Axon-Derived Netrin-1...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Remotely Produced and Axon-Derived Netrin-1...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Remotely Produced and Axon-Derived Netrin-1...
questionsmedicales.fr › Cellules › Neurones › Neurones dopaminergiques › Remotely Produced and Axon-Derived Netrin-1...
questionsmedicales.fr › Cellules › Neurones › Neurones GABAergiques › Remotely Produced and Axon-Derived Netrin-1...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Remotely Produced and Axon-Derived Netrin-1...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Remotely Produced and Axon-Derived Netrin-1...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Nétrines › Nétrine-1 › Remotely Produced and Axon-Derived Netrin-1...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Remotely Produced and Axon-Derived Netrin-1...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Substantia nigra › Remotely Produced and Axon-Derived Netrin-1...