Radiomics as a personalized medicine tool in lung cancer: Separating the hope from the hype.
Imaging biomarkers
Lung cancer
Personalized medicine
Radiomics
Journal
Lung cancer (Amsterdam, Netherlands)
ISSN: 1872-8332
Titre abrégé: Lung Cancer
Pays: Ireland
ID NLM: 8800805
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
12
03
2020
revised:
18
05
2020
accepted:
23
05
2020
pubmed:
21
6
2020
medline:
22
6
2021
entrez:
21
6
2020
Statut:
ppublish
Résumé
Radiomics has become a popular image analysis method in the last few years. Its key hypothesis is that medical images harbor biological, prognostic and predictive information that is not revealed upon visual inspection. In contrast to previous work with a priori defined imaging biomarkers, radiomics instead calculates image features at scale and uses statistical methods to identify those most strongly associated to outcome. This builds on years of research into computer aided diagnosis and pattern recognition. While the potential of radiomics to aid personalized medicine is widely recognized, several technical limitations exist which hinder biomarker translation. Aspects of the radiomic workflow lack repeatability or reproducibility under particular circumstances, which is a key requirement for the translation of imaging biomarkers into clinical practice. One of the most commonly studied uses of radiomics is for personalized medicine applications in Non-Small Cell Lung Cancer (NSCLC). In this review, we summarize reported methodological limitations in CT based radiomic analyses together with suggested solutions. We then evaluate the current NSCLC radiomics literature to assess the risk associated with accepting the published conclusions with respect to these limitations. We review different complementary scoring systems and initiatives that can be used to critically appraise data from radiomics studies. Wider awareness should improve the quality of ongoing and future radiomics studies and advance their potential as clinically relevant biomarkers for personalized medicine in patients with NSCLC.
Identifiants
pubmed: 32563015
pii: S0169-5002(20)30452-9
doi: 10.1016/j.lungcan.2020.05.028
pmc: PMC7383235
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
197-208Subventions
Organisme : Cancer Research UK
ID : C147/A18083
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C147/A25254
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C19221/A22746
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
Références
J Med Invest. 2019;66(1.2):35-37
pubmed: 31064950
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Nat Rev Drug Discov. 2010 May;9(5):363-6
pubmed: 20431568
Int J Med Phys Clin Eng Radiat Oncol. 2018 Aug;7(3):330-338
pubmed: 31131158
Clin Lung Cancer. 2019 Nov;20(6):e638-e651
pubmed: 31375452
Phys Med Biol. 2019 Aug 21;64(16):165012
pubmed: 31117063
JAMA Oncol. 2016 Dec 1;2(12):1636-1642
pubmed: 27541161
Sci Rep. 2018 Feb 5;8(1):2354
pubmed: 29403060
Radiology. 2016 Dec;281(3):947-957
pubmed: 27347764
Sci Rep. 2015 Aug 17;5:13087
pubmed: 26278466
PLoS One. 2017 Jan 3;12(1):e0169172
pubmed: 28046060
Acta Oncol. 2017 Nov;56(11):1544-1553
pubmed: 28885084
Tomography. 2016 Dec;2(4):374-377
pubmed: 30042968
J Med Imaging (Bellingham). 2018 Jan;5(1):011020
pubmed: 29487877
PLoS One. 2018 Nov 2;13(11):e0206108
pubmed: 30388114
Lung Cancer. 2019 Jun;132:28-35
pubmed: 31097090
Sci Rep. 2017 Apr 18;7:46349
pubmed: 28418006
Phys Med Biol. 2019 Jan 08;64(2):025007
pubmed: 30524018
Lung Cancer. 2020 Jan;139:73-79
pubmed: 31743889
Sci Rep. 2019 Jan 24;9(1):614
pubmed: 30679599
Radiother Oncol. 2017 Jun;123(3):363-369
pubmed: 28506693
Radiology. 2016 Feb;278(2):563-77
pubmed: 26579733
Ann Transl Med. 2019 Jun;7(12):259
pubmed: 31355226
Korean J Radiol. 2019 Oct;20(10):1431-1440
pubmed: 31544368
PLoS One. 2016 Dec 29;11(12):e0166550
pubmed: 28033372
Anticancer Res. 2018 Apr;38(4):2155-2160
pubmed: 29599334
Radiother Oncol. 2019 Jul;136:78-85
pubmed: 31015133
PLoS One. 2017 Sep 21;12(9):e0178524
pubmed: 28934225
Thorac Cancer. 2018 Oct;9(10):1235-1240
pubmed: 30070037
Radiother Oncol. 2017 Dec;125(3):385-391
pubmed: 29122358
Sci Rep. 2018 Jan 31;8(1):1922
pubmed: 29386574
Nat Rev Clin Oncol. 2017 Mar;14(3):169-186
pubmed: 27725679
PLoS One. 2018 Oct 4;13(10):e0205003
pubmed: 30286184
Eur J Radiol. 2020 Mar;124:108804
pubmed: 31926387
Medicine (Baltimore). 2017 May;96(21):e6993
pubmed: 28538408
Clin Lung Cancer. 2017 Nov;18(6):e425-e431
pubmed: 28623121
J Thorac Oncol. 2017 Apr;12(4):624-632
pubmed: 27923715
Cancer Manag Res. 2019 Aug 19;11:7825-7834
pubmed: 31695487
Medicine (Baltimore). 2019 Jan;98(1):e13963
pubmed: 30608433
Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:1268-1271
pubmed: 28268556
Thorac Cancer. 2019 Oct;10(10):1904-1912
pubmed: 31414580
Tomography. 2016 Dec;2(4):361-365
pubmed: 30042967
J Comput Assist Tomogr. 2017 Nov/Dec;41(6):995-1001
pubmed: 28708732
J Med Imaging (Bellingham). 2018 Jan;5(1):011005
pubmed: 29098170
Eur Urol. 2015 Jun;67(6):1142-1151
pubmed: 25572824
J Med Imaging (Bellingham). 2020 Jan;7(1):014504
pubmed: 32118090
Acta Oncol. 2018 Aug;57(8):1070-1074
pubmed: 29513054
Oncotarget. 2017 Nov 1;8(61):104393-104407
pubmed: 29262648
Med Phys. 2017 Mar;44(3):1050-1062
pubmed: 28112418
Br J Radiol. 2019 Feb;92(1094):20180228
pubmed: 30457885
Acad Radiol. 2020 Apr;27(4):497-507
pubmed: 31285150
PLoS One. 2014 Jul 15;9(7):e102107
pubmed: 25025374
Phys Med. 2020 Jan;69:176-182
pubmed: 31918370
Sci Rep. 2017 Aug 31;7(1):10117
pubmed: 28860628
Elife. 2017 Jul 21;6:
pubmed: 28731408
J Thorac Dis. 2019 Nov;11(11):4516-4528
pubmed: 31903240
Med Phys. 2019 Oct;46(10):4545-4552
pubmed: 31376283
Lung Cancer. 2019 Mar;129:75-79
pubmed: 30797495
Sci Rep. 2016 Mar 24;6:23428
pubmed: 27009765
Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1090-1097
pubmed: 29246722
J Natl Cancer Inst. 2018 Jan 1;110(1):
pubmed: 28922791
Radiology. 2014 Apr;271(1):6-27
pubmed: 24661292
Eur Radiol. 2018 Jul;28(7):2772-2778
pubmed: 29450713
Sci Rep. 2016 Sep 20;6:33860
pubmed: 27645803
J Nucl Med. 2011 Jan;52(1):48-55
pubmed: 21149474
Clin Radiol. 2010 Jul;65(7):517-21
pubmed: 20541651
Eur Radiol. 2019 Jun;29(6):2958-2967
pubmed: 30643940
Phys Med Biol. 2018 Nov 08;63(22):225003
pubmed: 30272571
Clin Transl Radiat Oncol. 2019 Jul 16;19:33-38
pubmed: 31417963
Sci Rep. 2018 Aug 29;8(1):13047
pubmed: 30158540
Med Phys. 2019 Jul;46(7):3091-3100
pubmed: 31002395
Front Oncol. 2016 Mar 30;6:71
pubmed: 27064691
Radiol Phys Technol. 2018 Mar;11(1):27-35
pubmed: 29209915
Sci Rep. 2018 Mar 16;8(1):4743
pubmed: 29549366
Sci Rep. 2018 Dec 17;8(1):17913
pubmed: 30559455
Med Phys. 2018 Nov;45(11):5317-5324
pubmed: 30133809
Radiat Oncol. 2017 Sep 25;12(1):158
pubmed: 28946909
Nat Commun. 2014 Jun 03;5:4006
pubmed: 24892406
Radiother Oncol. 2019 Jan;130:2-9
pubmed: 30416044
Phys Med Biol. 2020 Jan 13;65(1):015010
pubmed: 31835261
Tomography. 2016 Dec;2(4):430-437
pubmed: 28149958
J Thorac Dis. 2018 Apr;10(Suppl 7):S807-S819
pubmed: 29780627
Phys Med Biol. 2020 Jan 10;65(1):015009
pubmed: 31307024
Sci Rep. 2017 Apr 3;7(1):588
pubmed: 28373718
Radiother Oncol. 2015 Mar;114(3):345-50
pubmed: 25746350
Cancer Imaging. 2018 Dec 14;18(1):52
pubmed: 30547844
Radiother Oncol. 2016 Jun;119(3):480-6
pubmed: 27085484
Int J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):1121-8
pubmed: 26907916
Oncologist. 2018 Jul;23(7):806-813
pubmed: 29622699
Comput Methods Programs Biomed. 2018 Jun;159:23-30
pubmed: 29650315
Med Phys. 2019 Nov;46(11):5075-5085
pubmed: 31494946
Radiother Oncol. 2016 Aug;120(2):258-66
pubmed: 27296412
Chin J Cancer Res. 2019 Aug;31(4):641-652
pubmed: 31564807
Acad Radiol. 2018 Dec;25(12):1548-1555
pubmed: 29572049
Med Phys. 2017 Aug;44(8):4341-4349
pubmed: 28464316
Eur Radiol. 2019 Sep;29(9):4742-4750
pubmed: 30778717
Respir Res. 2018 Oct 10;19(1):199
pubmed: 30305102
Eur Radiol. 2019 May;29(5):2196-2206
pubmed: 30523451
Invest Radiol. 2015 Nov;50(11):757-65
pubmed: 26115366
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
J Med Imaging (Bellingham). 2018 Jan;5(1):011013
pubmed: 29285518
Eur Radiol. 2020 Jun 1;:
pubmed: 32483644
Radiother Oncol. 2017 Oct;125(1):147-153
pubmed: 28797700
Comput Math Methods Med. 2019 Feb 6;2019:8790694
pubmed: 30881480
Sci Rep. 2018 Jul 12;8(1):10545
pubmed: 30002441
Phys Med. 2019 Feb;58:141-148
pubmed: 30824145
Eur Radiol. 2018 Dec;28(12):5121-5128
pubmed: 29869172
Cancer Res. 2017 Jul 15;77(14):3922-3930
pubmed: 28566328
Radiat Oncol. 2018 Oct 5;13(1):197
pubmed: 30290849
J Thorac Oncol. 2017 Mar;12(3):467-476
pubmed: 27903462
J Comput Assist Tomogr. 2019 Mar/Apr;43(2):300-306
pubmed: 30664116
Lung Cancer. 2018 Oct;124:6-11
pubmed: 30268481
PLoS One. 2019 May 7;14(5):e0216480
pubmed: 31063500
AJR Am J Roentgenol. 2018 Jul;211(1):109-113
pubmed: 29667885
Med Phys. 2015 Dec;42(12):6784-97
pubmed: 26632036
Sci Rep. 2018 Feb 19;8(1):3284
pubmed: 29459639
Oncologist. 2019 Nov;24(11):e1156-e1164
pubmed: 30936378
Elife. 2017 Sep 06;6:
pubmed: 28876221
Strahlenther Onkol. 2019 Nov 13;:
pubmed: 31722061
Med Phys. 2018 Jul;45(7):3449-3459
pubmed: 29763967
Nat Rev Clin Oncol. 2017 Dec;14(12):749-762
pubmed: 28975929
Eur J Radiol. 2019 Sep;118:32-37
pubmed: 31439255
Int J Comput Assist Radiol Surg. 2020 Jan;15(1):163-172
pubmed: 31722085