Regulatory landscape in brain development and disease.
Journal
Current opinion in genetics & development
ISSN: 1879-0380
Titre abrégé: Curr Opin Genet Dev
Pays: England
ID NLM: 9111375
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
30
01
2020
revised:
06
04
2020
accepted:
01
05
2020
pubmed:
22
6
2020
medline:
2
7
2021
entrez:
22
6
2020
Statut:
ppublish
Résumé
Although many regulatory elements in the non-coding genome are linked to brain development and disease, deciphering their function has been challenging due to the lack of a genomic toolbox. However, recent advances in high throughput sequencing techniques have allowed us to begin decoding its function, enhancing our understanding of the regulatory landscape that underpins human traits and brain disorders. Here, we review how the regulatory landscape of the human brain undergoes dynamic changes across neurodevelopment, different cell types, and human evolution. We then discuss how regulatory landscapes shed light onto the molecular basis of neuropsychiatric disorders and guide the development of specifically targeted molecular therapies. Finally, we offer some thoughts on how these discoveries might impact the direction of future studies.
Identifiants
pubmed: 32563855
pii: S0959-437X(20)30058-7
doi: 10.1016/j.gde.2020.05.007
pmc: PMC7746596
mid: NIHMS1595255
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
53-60Subventions
Organisme : NIMH NIH HHS
ID : DP2 MH122403
Pays : United States
Organisme : NIMH NIH HHS
ID : R00 MH113823
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066871
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA051921
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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