Can hyperimmune anti-CMV globulin substitute for convalescent plasma for treatment of COVID-19?
COVID-19
Hyperimmune anti-CMV globulin
Renal transplantation
SARS-CoV-2
Journal
Medical hypotheses
ISSN: 1532-2777
Titre abrégé: Med Hypotheses
Pays: United States
ID NLM: 7505668
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
23
04
2020
revised:
18
05
2020
accepted:
28
05
2020
pubmed:
22
6
2020
medline:
23
12
2020
entrez:
22
6
2020
Statut:
ppublish
Résumé
Information on treatment of COVID-19 infection in renal transplant recipients is scarce, especially in symptomatic patients and patients with recent major clinical events. This group of patients suffers from different opportunistic infections which may coexist with COVID-19. Currently available expert opinions suggest reduction of immunosuppression therapy for renal transplant recipients with symptomatic COVID-19 infection with either antiviral drugs, hydroxychloroquine and/or azithromycin. Inspired by our experience in treatment of CMV pneumonia and literature data on the potential benefit of convalescent plasma for treatment of different viral diseases we suggest use of the hyperimmune anti-CMV gamma globulins in addition to other available therapies. Besides the immunosuppression reduction which is supposed to be beneficial, immunoglobulins with their immunomodulatory effects and possible antiviral role, may increase a possibility for favorable outcome.
Identifiants
pubmed: 32563969
pii: S0306-9877(20)30949-X
doi: 10.1016/j.mehy.2020.109903
pmc: PMC7261461
pii:
doi:
Substances chimiques
Immunoglobulins
0
Immunoglobulins, Intravenous
0
cytomegalovirus-specific hyperimmune globulin
129L90A25N
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
109903Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Références
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