Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis.
Blood pressure
Breastfeeding
Children
Fatty acids
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
16
12
2019
accepted:
15
06
2020
pubmed:
22
6
2020
medline:
24
6
2021
entrez:
22
6
2020
Statut:
ppublish
Résumé
It is controversial whether a higher intake of n-3 long-chain polyunsaturated fatty acids (n-3 LC PUFA) through breastfeeding is associated or not to a lower blood pressure (BP) during childhood. We aimed to clarify this point by undertaking a meta-analysis involving the data from seven European birth cohorts. We searched https://www.birthcohort.net for studies that had collected breast milk samples, and had at least one BP measurement in childhood. Principal investigators were contacted, and all agreed to share data. One additional study was identified by contacts with the principal investigators. For each cohort, we analyzed the association of breast milk n-3 LC PUFAs with systolic and diastolic BP with linear mixed effects models or linear regression, and pooled the estimates with a random effects model. We also investigated age-specific and sex-specific associations. A total of 2188 participants from 7 cohorts were included. Overall, no associations between breast milk n-3 LC PUFAs and BP were observed. In the pooled analysis, each 0.1 wt% increment in breast milk docosahexaenoic acid (DHA) was associated with a 1.19 (95% CI - 3.31, 0.94) mmHg lower systolic BP. Associations were similar for boys and girls and at different ages. In this individual participant meta-analysis, we found no evidence for an association between breast milk n-3 LC PUFAs and BP.
Identifiants
pubmed: 32564149
doi: 10.1007/s00394-020-02310-4
pii: 10.1007/s00394-020-02310-4
pmc: PMC7900030
doi:
Substances chimiques
Fatty Acids, Omega-3
0
Fatty Acids, Unsaturated
0
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
989-998Subventions
Organisme : Hartstichting
ID : 2013T025
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