Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study.
Alcohol
Atrophy
Brain volume
Longitudinal
MRI
Mid-life
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
24
04
2020
accepted:
12
06
2020
revised:
11
06
2020
pubmed:
22
6
2020
medline:
22
6
2021
entrez:
22
6
2020
Statut:
ppublish
Résumé
Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use and brain volume change over 2 years in middle-aged subjects. A sample of 162 subjects (aged 40-59 at baseline) from the PREVENT-Dementia programme underwent MRI scans on two separate occasions (mean interval 734 days; SD 42 days). We measured longitudinal rates of brain atrophy using the FSL Siena toolbox, and change in hippocampal volume from segmentation in SPM. Controlling for age and sex, there were no significant associations of either total brain, ventricular, or hippocampal volume change with alcohol consumption. Adjusting for lifestyle, demographic and vascular risk factors did not alter this. We did not find any evidence of influence of alcohol consumption on changes in brain volume over a 2-year period in 40-60-year-olds.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use and brain volume change over 2 years in middle-aged subjects.
METHODS
METHODS
A sample of 162 subjects (aged 40-59 at baseline) from the PREVENT-Dementia programme underwent MRI scans on two separate occasions (mean interval 734 days; SD 42 days). We measured longitudinal rates of brain atrophy using the FSL Siena toolbox, and change in hippocampal volume from segmentation in SPM.
RESULTS
RESULTS
Controlling for age and sex, there were no significant associations of either total brain, ventricular, or hippocampal volume change with alcohol consumption. Adjusting for lifestyle, demographic and vascular risk factors did not alter this.
CONCLUSIONS
CONCLUSIONS
We did not find any evidence of influence of alcohol consumption on changes in brain volume over a 2-year period in 40-60-year-olds.
Identifiants
pubmed: 32564151
doi: 10.1007/s00415-020-10000-8
pii: 10.1007/s00415-020-10000-8
pmc: PMC7578123
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3282-3286Subventions
Organisme : The Dunhill Medical Trust
ID : R380R/1114
Pays : United Kingdom
Organisme : Alzheimer's Association
ID : TriBEKa-17-519007
Pays : United States
Références
Lancet. 2002 Jan 26;359(9303):281-6
pubmed: 11830193
J Gerontol A Biol Sci Med Sci. 2015 Oct;70(10):1248-54
pubmed: 25881581
Alzheimers Dement. 2018 Feb;14(2):253-258
pubmed: 29156222
J Neurol Neurosurg Psychiatry. 2020 Feb;91(2):158-161
pubmed: 31806724
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
BMJ. 2017 Jun 6;357:j2353
pubmed: 28588063
Psychol Med. 2017 Oct;47(13):2288-2301
pubmed: 28374654
Am J Alzheimers Dis Other Demen. 2015 Jun;30(4):364-74
pubmed: 25202027
Arch Neurol. 2008 Oct;65(10):1363-7
pubmed: 18852353
Psychol Med. 2007 Jul;37(7):1015-25
pubmed: 17112402
Alzheimers Dement. 2017 Oct;13(10):1089-1097
pubmed: 28365321
BMJ Open. 2012 Nov 19;2(6):
pubmed: 23166135
Clin Nutr. 2014 Aug;33(4):662-7
pubmed: 24011900