The impact of fatigue on patients with psoriatic arthritis: a multi-center study of the TLAR-network.
Disease activity
Fatigue
Lassitude
Outcome measure
Psoriatic arthritis
Journal
Rheumatology international
ISSN: 1437-160X
Titre abrégé: Rheumatol Int
Pays: Germany
ID NLM: 8206885
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
13
04
2020
accepted:
13
06
2020
pubmed:
22
6
2020
medline:
3
8
2021
entrez:
22
6
2020
Statut:
ppublish
Résumé
Fatigue is a substantial problem in patients with psoriatic arthritis (PsA) that needs to be considered in the core set of domains. This study aimed to evaluate fatigue and its relationship with disease parameters, functional disability, anxiety, depression, quality of life, and correlation with disease activity as determined by various scales. A total of 1028 patients (677 females, 351 males) with PsA who met the CASPAR criteria were included [Turkish League Against Rheumatism (TLAR) Network multicenter study]. The demographic features and clinical conditions of the patients were recorded. Correlations between fatigue score and clinical parameters were evaluated using the Disease Activity Score 28 (DAS28), Disease Activity in Psoriatic Arthritis (DAPSA), Clinical DAPSA (cDAPSA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Fibromyalgia Rapid Screening Tool (FiRST), minimal disease activity (MDA), and very low disease activity (VLDA). Fatigue was assessed with the Functional Assessment of Chronic Illness Therapy (FACIT-F) and a 10-point VAS (VAS-F). The mean age of the patients was 47 (SD: 12.2) years, and the mean disease duration was 6.4 (SD: 7.3) years. The mean VAS-F score was 5.1 (SD: 2.7), with fatigue being absent or mild, moderate, and severe in 12.8%, 24.6%, and 62.5% of the patients, respectively. Fatigue scores were significantly better in patients with DAS28 remission, DAPSA remission, cDAPSA remission, MDA, and VLDA (p < 0.001). Fatigue scores significantly increased with increasing disease activity levels on the DAS28, DAPSA, and cDAPSA (p < 0.001). VAS-F scores showed correlations with the scores of the BASDAI, BASFI, PsAQoL, HAD-A, FiRST, pain VAS, and PtGA. FiRST scores showed fibromyalgia in 255 (24.8%) patients. FACIT-F and VAS-F scores were significantly higher in patients with fibromyalgia (p < 0.001). In regression analysis, VLDA, BASDAI score, FiRST score, high education level, HAD-Anxiety, and BMI showed independent associations with fatigue. Our findings showed that fatigue was a common symptom in PsA and disease activity was the most substantial predictor, with fatigue being less in patients in remission, MDA, and VLDA. Other correlates of fatigue were female gender, educational level, anxiety, quality of life, function, pain, and fibromyalgia.
Identifiants
pubmed: 32564159
doi: 10.1007/s00296-020-04628-y
pii: 10.1007/s00296-020-04628-y
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1803-1815Références
Coates LC, Helliwell PS (2017) Psoriatic arthritis state of the art review. Clin Med 17:65–70. https://doi.org/10.7861/clinmedicine.17-1-65
doi: 10.7861/clinmedicine.17-1-65
Nikolaus S, Bode C, Taal E, van de Laar MA (2013) Fatigue and factors related to fatigue in rheumatoid arthritis: a systematic review. Arthritis Care Res 65:1128–1146. https://doi.org/10.1002/acr.21949
doi: 10.1002/acr.21949
Tsutsui H, Kikuchi H, Oguchi H, Nomura K, Ohkuba T (2020) Identification of physical and psychosocial problems based on symptoms in patients with Behçet’s disease. Rheumatol Int 40:81–89. https://doi.org/10.1007/s00296-019-04488-1
doi: 10.1007/s00296-019-04488-1
pubmed: 31802209
Carneiro C, Chaves M, Verardino G, Frade AP, Coscarelli PG, Bianchi WA, Ramos ESM, Carneiro S (2017) Evaluation of fatigue and its correlation with quality of life index, anxiety symptoms, depression and activity of disease in patients with psoriatic arthritis. Clin Cosmet Investig Dermatol 10:155–163. https://doi.org/10.2147/CCID.S124886
doi: 10.2147/CCID.S124886
pubmed: 28507445
pmcid: 5428766
Husted JA, Tom BD, Schentag CT, Farewell VT, Gladman DD (2009) Occurrence and correlates of fatigue in psoriatic arthritis. Ann Rheum Dis 68:1553–1558. https://doi.org/10.1136/ard.2008.098202
doi: 10.1136/ard.2008.098202
pubmed: 18930991
Dupond JL (2011) Fatigue in patients with rheumatic diseases. Joint Bone Spine 78:156–160. https://doi.org/10.1016/j.jbspin.2010.05.002
doi: 10.1016/j.jbspin.2010.05.002
pubmed: 20646948
Boksem MA, Tops M (2008) Mental fatigue: costs and benefits. Brain Res Rev 59:125–139. https://doi.org/10.1016/j.brainresrev.2008.07.001
doi: 10.1016/j.brainresrev.2008.07.001
pubmed: 18652844
Morris G, Berk M, Galecki P, Walder K, Maes M (2016) The neuro-immune pathophysiology of central and peripheral fatigue in systemic immune-inflammatory and neuro-immune diseases. Mol Neurobiol 53:1195–1219. https://doi.org/10.1007/s12035-015-9090-9
doi: 10.1007/s12035-015-9090-9
pubmed: 25598355
Davies K, Mirza K, Tarn J, Howard-Tripp N, Bowman SJ, Lendrem D, Ng WF (2019) Fatigue in Primary Sjogren's Syndrome (pSS) is associated with lower levels of proinflammatory cytokines: a validation study. Rheumatol Int 39:1867–1873. https://doi.org/10.1007/s00296-019-04354-0
doi: 10.1007/s00296-019-04354-0
pubmed: 31250166
pmcid: 6791914
Sandikci SC, Ozbalkan Z (2015) Fatigue in rheumatic diseases. Eur J Rheumatol 2:109–113. https://doi.org/10.5152/eurjrheum.2015.0029
doi: 10.5152/eurjrheum.2015.0029
pubmed: 27708942
pmcid: 5047251
Kalyoncu U, Bayindir Ö, Ferhat Öksüz M, Doğru A, Kimyon G, Tarhan EF, Erden A, Yavuz Ş, Can M, Çetin GY, Kılıç L, Küçükşahin O, Omma A, Ozisler C, Solmaz D, Bozkirli EDE, Akyol L, Pehlevan SM, Gunal EK, Arslan F, Yılmazer B, Atakan N, Aydın SZ (2016) The Psoriatic Arthritis Registry of Turkey: results of a multicentre registry on 1081 patients. Rheumatology 56:279–286. https://doi.org/10.1093/rheumatology/kew375
doi: 10.1093/rheumatology/kew375
pubmed: 27794533
Gorlier C, Puyraimond-Zemmour D, Kiltz U, Orbai A-M, Leung YY, Palominos P, Cañete JD, Scrivo R, Balanescu A, Dernis E, Talli S, Ruyssen-Witrand A, Soubrier M, Aydin S, Eder L, Gaydukova I, Lubrano E, Coates L, Kalyoncu U, Smolen J, De Wit M, Gossec L (2018) SAT0318 Do patients in remission in psoriatic arthritis, have less fatigue? And does this depend on the definition of remission? An analysis of 304 patients. Ann Rheum Dis 77:1023–1024. https://doi.org/10.1136/annrheumdis-2018-eular.3106
doi: 10.1136/annrheumdis-2018-eular.3106
Tucker LJ, Coates LC, Helliwell PS (2019) Assessing disease activity in Psoriatic Arthritis: a literature review. Rheumatol Ther 6:23–32. https://doi.org/10.1007/s40744-018-0132-4
doi: 10.1007/s40744-018-0132-4
Mease PJ, Kavanaugh A, Coates LC, McInnes IB, Hojnik M, Zhang Y, Anderson JK, Dorr AP, Gladman DD (2017) Prediction and benefits of minimal disease activity in patients with psoriatic arthritis and active skin disease in the ADEPT trial. RMD Open 3:e000415. https://doi.org/10.1136/rmdopen-2016-000415
doi: 10.1136/rmdopen-2016-000415
pubmed: 29225916
pmcid: 5708306
Wolfe F, Hawley DJ, Wilson K (1996) The prevalence and meaning of fatigue in rheumatic disease. J Rheumatol 23:1407–1417
pubmed: 8856621
Marques M, De Gucht V, Leal I, Maes S (2013) A cross-cultural perspective on psychological determinants of chronic fatigue syndrome: a comparison between a Portuguese and a Dutch patient sample. Int J Behav Med 20:229–238. https://doi.org/10.1007/s12529-012-9265-y
doi: 10.1007/s12529-012-9265-y
pubmed: 22972378
Gossec L, de Wit M, Kiltz U, Braun J, Kalyoncu U, Scrivo R, Maccarone M, Carton L, Otsa K, Sooaar I, Heiberg T, Bertheussen H, Canete JD, Sanchez Lombarte A, Balanescu A, Dinte A, de Vlam K, Smolen JS, Stamm T, Niedermayer D, Bekes G, Veale D, Helliwell P, Parkinson A, Luger T, Kvien TK (2014) A patient-derived and patient-reported outcome measure for assessing psoriatic arthritis: elaboration and preliminary validation of the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire, a 13-country EULAR initiative. Ann Rheum Dis 73:1012–1019. https://doi.org/10.1136/annrheumdis-2014-205207
doi: 10.1136/annrheumdis-2014-205207
pubmed: 24790067
Orbai AM, de Wit M, Mease PJ, Callis Duffin K, Elmamoun M, Tillett W, Campbell W, FitzGerald O, Gladman DD, Goel N, Gossec L, Hoejgaard P, Leung YY, Lindsay C, Strand V, van der Heijde DM, Shea B, Christensen R, Coates L, Eder L, McHugh N, Kalyoncu U, Steinkoenig I, Ogdie A (2017) Updating the Psoriatic Arthritis (PsA) core domain set: a report from the PsA workshop at OMERACT 2016. J Rheumatol 44:1522–1528. https://doi.org/10.3899/jrheum.160904.C1
doi: 10.3899/jrheum.160904.C1
pubmed: 28148697
pmcid: 5538953
Taylor W, Gladman D, Helliwell P, Marchesoni A, Mease P, Mielants H (2006) Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum 54:2665–2673. https://doi.org/10.1002/art.21972
doi: 10.1002/art.21972
Cheng CY, Chou YH, Wang P, Tsai JM, Liou SR (2015) Survey of trend and factors in perinatal maternal fatigue. Nurs Health Sci 17:64–70. https://doi.org/10.1111/nhs.12149
doi: 10.1111/nhs.12149
pubmed: 24835296
Yang S, Chu S, Gao Y, Ai Q, Liu Y, Li X, Chen N (2019) A narrative review of cancer-related fatigue (CRF) and its possible pathogenesis. Cells 8:738. https://doi.org/10.3390/cells8070738
doi: 10.3390/cells8070738
pmcid: 6679212
Tälli S, Etcheto A, Fautrel B, Balanescu A, Braun J, Cañete JD, de Vlam K, de Wit M, Heiberg T, Helliwell P, Kalyoncu U, Kiltz U, Maccarone M, Niedermayer D, Otsa K, Scrivo R, Smolen JS, Stamm T, Veale DJ, Kvien TK, Gossec L (2016) Patient global assessment in psoriatic arthritis - what does it mean? An analysis of 223 patients from the Psoriatic arthritis impact of disease (PsAID) study. Joint Bone Spine 83:335–340. https://doi.org/10.1016/j.jbspin.2015.06.018
doi: 10.1016/j.jbspin.2015.06.018
pubmed: 26677994
Kucukdeveci AA, Sahin H, Ataman S, Griffiths B, Tennant A (2004) Issues in cross-cultural validity: example from the adaptation, reliability, and validity testing of a Turkish version of the Stanford Health Assessment Questionnaire. Arthritis Rheum 51:14–19. https://doi.org/10.1002/art.20091
doi: 10.1002/art.20091
pubmed: 14872450
Karatepe AG, Akkoc Y, Akar S, Kirazli Y, Akkoc N (2005) The Turkish versions of the Bath Ankylosing Spondylitis and Dougados Functional Indices: reliability and validity. Rheumatol Int 25:612–618. https://doi.org/10.1007/s00296-004-0481-x
doi: 10.1007/s00296-004-0481-x
pubmed: 15248085
McKenna SP, Doward LC, Whalley D, Tennant A, Emery P, Veale DJ (2004) Development of the PsAQoL: a quality of life instrument specific to psoriatic arthritis. Ann Rheum Dis 63:162–169. https://doi.org/10.1136/ard.2003.006296
doi: 10.1136/ard.2003.006296
pubmed: 14722205
pmcid: 1754880
Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–370. https://doi.org/10.1111/j.1600-0447.1983.tb09716.x
doi: 10.1111/j.1600-0447.1983.tb09716.x
pubmed: 6880820
Celiker R, Altan L, Rezvani A, Aktas I, Tastekin N, Dursun E, Dursun N, Sarıkaya S, Ozdolap S, Akgun K, Zateri C, Birtane M (2017) Reliability and validity of the Turkish version of the fibromyalgia rapid screening tool (FiRST). J Phys Ther Sci 29:340–344. https://doi.org/10.1589/jpts.29.340
doi: 10.1589/jpts.29.340
pubmed: 28265170
pmcid: 5333001
Feldman SR, Fleischer AB Jr, Reboussin DM, Rapp SR, Exum ML, Clark AR, Nurre L (1996) The self-administered psoriasis area and severity index is valid and reliable. J Invest Dermatol 106:183–186
doi: 10.1111/1523-1747.ep12329912
Khallaf MK, AlSergany MA, El-Saadany HM, Abo El-Hawa MA, Ahmed RAM (2019) Assessment of fatigue and functional impairment in patients with rheumatic diseases. Egypt Rheumatol 42:51–56. https://doi.org/10.1016/j.ejr.2019.04.009
doi: 10.1016/j.ejr.2019.04.009
Webster K, Cella D, Yost K (2003) The functional assessment of chronic illness therapy (FACIT) measurement system: properties, applications, and interpretation. Health Qual Life Outcomes 1:79–79. https://doi.org/10.1186/1477-7525-1-79
doi: 10.1186/1477-7525-1-79
pubmed: 14678568
pmcid: 317391
Piper BF, Cella D (2010) Cancer-related fatigue: definitions and clinical subtypes. J Natl Compr Canc Netw 8:958–966. https://doi.org/10.6004/jnccn.2010.0070
doi: 10.6004/jnccn.2010.0070
pubmed: 20870639
Helliwell PS, FitzGerald O, Fransen J (2014) Composite disease activity and responder indices for Psoriatic Arthritis: a report from the GRAPPA 2013 Meeting on development of cut-offs for both disease activity states and response. J Rheumatol 41:1212–1217. https://doi.org/10.3899/jrheum.140172
doi: 10.3899/jrheum.140172
pubmed: 24882854
Schoels M, Aletaha D, Funovits J, Kavanaugh A, Baker D, Smolen JS (2010) Application of the DAREA/DAPSA score for assessment of disease activity in psoriatic arthritis. Ann Rheum Dis 69:1441–1447. https://doi.org/10.1136/ard.2009.122259
doi: 10.1136/ard.2009.122259
pubmed: 20525844
Lubrano E, De Socio A, Perrotta FM (2017) Comparison of composite indices tailored for Psoriatic Arthritis treated with csDMARD and bDMARD: a cross-sectional analysis of a longitudinal cohort. J Rheumatol 44:1159–1164. https://doi.org/10.3899/jrheum.170112
doi: 10.3899/jrheum.170112
pubmed: 28572467
Schoels MM, Aletaha D, Alasti F, Smolen JS (2016) Disease activity in psoriatic arthritis (PsA): defining remission and treatment success using the DAPSA score. Ann Rheum Dis 75:811–818. https://doi.org/10.1136/annrheumdis-2015-207507
doi: 10.1136/annrheumdis-2015-207507
pubmed: 26269398
Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 21:2286–2291
Coates LC, Fransen J, Helliwell PS (2010) Defining minimal disease activity in psoriatic arthritis: a proposed objective target for treatment. Ann Rheum Dis 69:48–53. https://doi.org/10.1136/ard.2008.102053
doi: 10.1136/ard.2008.102053
pubmed: 19147615
Coates LC, Rahman P, Psaradellis E, Rampakakis E, Osborne B, Lehman AJ, Nantel F (2019) Validation of new potential targets for remission and low disease activity in psoriatic arthritis in patients treated with golimumab. Rheumatology (Oxford) 58:522–526. https://doi.org/10.1093/rheumatology/key359
doi: 10.1093/rheumatology/key359
Bergman MJ, Shahouri SH, Shaver TS, Anderson JD, Weidensaul DN, Busch RE, Wang S, Wolfe F (2009) Is fatigue an inflammatory variable in rheumatoid arthritis (RA)? Analyses of fatigue in RA, osteoarthritis, and fibromyalgia. J Rheumatol 36:2788–2794. https://doi.org/10.3899/jrheum.090561
doi: 10.3899/jrheum.090561
pubmed: 19918042
Overman CL, Kool MB, Da Silva JA, Geenen R (2016) The prevalence of severe fatigue in rheumatic diseases: an international study. Clin Rheumatol 35:409–415. https://doi.org/10.1007/s10067-015-3035-6
doi: 10.1007/s10067-015-3035-6
pubmed: 26272057
Gudu T, Etcheto A, de Wit M, Heiberg T, Maccarone M, Balanescu A, Balint PV, Niedermayer DS, Canete JD, Helliwell P, Kalyoncu U, Kiltz U, Otsa K, Veale DJ, de Vlam K, Scrivo R, Stamm T, Kvien TK, Gossec L (2016) Fatigue in psoriatic arthritis—a cross-sectional study of 246 patients from 13 countries. Joint Bone Spine 83:439–443. https://doi.org/10.1016/j.jbspin.2015.07.017
doi: 10.1016/j.jbspin.2015.07.017
pubmed: 27055727
Skougaard M, Jørgensen TS, Rifbjerg-Madsen S, Coates LC, Egeberg A, Amris K, Dreyer L, Højgaard P, Guldberg-Møller J, Merola JF, Frederiksen P, Gudbergsen H, Kristensen LE (2019) Relationship between fatigue and inflammation, disease duration, and chronic pain in Psoriatic Arthritis: an observational DANBIO Registry Study. J Rheumatol 47:548–552. https://doi.org/10.3899/jrheum.181412
doi: 10.3899/jrheum.181412
pubmed: 31308213
Husted JA, Tom BD, Farewell VT, Gladman DD (2010) Longitudinal analysis of fatigue in psoriatic arthritis. J Rheumatol 37:1878–1884. https://doi.org/10.3899/jrheum.100179
doi: 10.3899/jrheum.100179
pubmed: 20595286
Minnock P, Kirwan J, Veale D, Fitzgerald O, Bresnihan B (2010) Fatigue is an independent outcome measure and is sensitive to change in patients with psoriatic arthritis. Clin Exp Rheumatol 28:401–404
pubmed: 20525443
Tobin AM, Sadlier M, Collins P, Rogers S, FitzGerald O, Kirby B (2017) Fatigue as a symptom in psoriasis and psoriatic arthritis: an observational study. Br J Dermatol 176:827–828. https://doi.org/10.1111/bjd.15258
doi: 10.1111/bjd.15258
pubmed: 28005279
Jørgensen TS, Skougaard M, Ballegaard C, Mease P, Strand V, Dreyer L, Kristensen LE (2018) THU0332 Fatigue remains a dominatng symptom despite tumour necrosis factor inhibitor therapy in psoriatic arthritis: a population-based cohort study. Ann Rheum Dis 77:384–385. https://doi.org/10.1136/annrheumdis-2018-eular.6780
doi: 10.1136/annrheumdis-2018-eular.6780
Mueller C, Lin JC, Thannickal HH, Daredia A, Denney TS, Beyers R, Younger JW (2020) No evidence of abnormal metabolic or inflammatory activity in the brains of patients with rheumatoid arthritis: results from a preliminary study using whole-brain magnetic resonance spectroscopic imaging (MRSI). Clin Rheumatol 39:1765–1774. https://doi.org/10.1007/s10067-019-04923-5
doi: 10.1007/s10067-019-04923-5
pubmed: 32002761
pmcid: 7237391
Druce K, McBeth J (2019) Central sensitization predicts greater fatigue independently of musculoskeletal pain. Rheumatology (Oxford) 58:1923–1927. https://doi.org/10.1093/rheumatology/kez028
doi: 10.1093/rheumatology/kez028
Magrey MN, Antonelli M, James N, Khan MA (2013) High frequency of fibromyalgia in patients with psoriatic arthritis: a pilot study. Arthritis 2013:1–4. https://doi.org/10.1155/2013/762921
doi: 10.1155/2013/762921
Ulus Y, Akyol Y, Bilgici A, Kuru Ö (2019) the impact of the presence of fibromyalgia on fatigue in patients with psoriatic arthritis: comparison with controls. Adv Rheumatol 60:1. https://doi.org/10.1186/s42358-019-0104-6
doi: 10.1186/s42358-019-0104-6
pubmed: 31892345
Katz P, Margaretten M, Trupin L, Schmajuk G, Yazdany J, Yelin E (2016) Role of sleep disturbance, depression, obesity, and physical inactivity in fatigue in Rheumatoid Arthritis. Arthritis Care Res 68:81–90. https://doi.org/10.1002/acr.22577
doi: 10.1002/acr.22577
Hewlett S, Chalder T, Choy E, Cramp F, Davis B, Dures E, Nicholls C, Kirwan J (2011) Fatigue in rheumatoid arthritis: time for a conceptual model. Rheumatology (Oxford) 50:1004–1006. https://doi.org/10.1093/rheumatology/keq282
doi: 10.1093/rheumatology/keq282
Geenen R, Overman CL, Christensen R, Asenlof P, Capela S, Huisinga KL, Husebo MEP, Koke AJA, Paskins Z, Pitsillidou IA, Savel C, Austin J, Hassett AL, Severijns G, Stoffer-Marx M, Vlaeyen JWS, Fernandez-de-Las-Penas C, Ryan SJ, Bergman S (2018) EULAR recommendations for the health professional's approach to pain management in inflammatory arthritis and osteoarthritis. Ann Rheum Dis 77:797–807. https://doi.org/10.1136/annrheumdis-2017-212662
doi: 10.1136/annrheumdis-2017-212662
pubmed: 29724726
Wolfe F (2004) Fatigue assessments in rheumatoid arthritis: comparative performance of visual analog scales and longer fatigue questionnaires in 7760 patients. J Rheumatol 31:1896–1902
pubmed: 15468350