S100 family proteins in inflammation and beyond.

Animals Anti-Inflammatory Agents / therapeutic use Biomarkers / metabolism Humans Inflammation / drug therapy S100 Proteins / metabolism
Ca(2+) signaling Cancer Cardiomyocytes Diabetes EF-hand motif Inflammasome Inflammatory response Inhibitors Myocardial infarction Obesity Phagocytes Psoriasis S100 proteins Sarcoplasmic reticulum WBC

Journal

Advances in clinical chemistry
ISSN: 2162-9471
Titre abrégé: Adv Clin Chem
Pays: United States
ID NLM: 2985173R

Informations de publication

Date de publication:
2020
Historique:
entrez: 23 6 2020
pubmed: 23 6 2020
medline: 26 1 2021
Statut: ppublish

Résumé

The S100 family proteins possess a variety of intracellular and extracellular functions. They interact with multiple receptors and signal transducers to regulate pathways that govern inflammation, cell differentiation, proliferation, energy metabolism, apoptosis, calcium homeostasis, cell cytoskeleton and microbial resistance. S100 proteins are also emerging as novel diagnostic markers for identifying and monitoring various diseases. Strategies aimed at targeting S100-mediated signaling pathways hold a great potential in developing novel therapeutics for multiple diseases. In this chapter, we aim to summarize the current knowledge about the role of S100 family proteins in health and disease with a major focus on their role in inflammatory conditions.

Identifiants

DOI: 10.1016/bs.acc.2020.02.006 PMID: 32564786
pubmed: 32564786
pii: S0065-2423(20)30018-4
doi: 10.1016/bs.acc.2020.02.006
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Biomarkers 0
S100 Proteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

173-231

Informations de copyright

© 2020 Elsevier Inc. All rights reserved.

Auteurs

Gopalkrishna Sreejit (G)

Department of Surgery, Ohio State University, Columbus, OH, United States.

Michelle C Flynn (MC)

Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.

Mallikarjun Patil (M)

Department of Biomedical Engineering, Schools of Medicine and Engineering, University of Alabama at Birmingham, Birmingham, AL, United States.

Prasanna Krishnamurthy (P)

Department of Biomedical Engineering, Schools of Medicine and Engineering, University of Alabama at Birmingham, Birmingham, AL, United States.

Andrew J Murphy (AJ)

Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia; Department of Immunology, Monash University, Melbourne, VIC, Australia.

Prabhakara R Nagareddy (PR)

Department of Surgery, Ohio State University, Columbus, OH, United States. Electronic address: prabhakara.nagareddy@osumc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › S100 family proteins in inflammation and beyond.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › S100 family proteins in inflammation and beyond.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › S100 family proteins in inflammation and beyond.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › S100 family proteins in inflammation and beyond.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › S100 family proteins in inflammation and beyond.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines S100 › S100 family proteins in inflammation and beyond.