The interaction between mitochondrial haplogroups (M7a/D) and physical activity on adiponectin in a Japanese population.
Adiponectin
Mitochondrial gene polymorphism
Physical activity
Journal
Mitochondrion
ISSN: 1872-8278
Titre abrégé: Mitochondrion
Pays: Netherlands
ID NLM: 100968751
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
17
02
2020
revised:
09
05
2020
accepted:
10
06
2020
pubmed:
23
6
2020
medline:
30
3
2021
entrez:
23
6
2020
Statut:
ppublish
Résumé
Mitochondrial haplogroups F, A, and M7a are associated with increased risks of lifestyle diseases, while haplogroups N9 and D are associated with decreased risks of lifestyle diseases or with longevity. The current study determined the existence of interactions between 5 selected haplogroups and physical activity (PA) on total and high-molecular-weight (HMW) adiponectin in 3,994 men and 6,014 women. The interactions between haplogroups (M7a/D) and PA on adiponectin were significant in men (total and HMW: P-interaction = 0.041 and 0.011). The positive association of PA with adiponectin in men carrying haplogroup M7a is attenuated in comparison to men carrying haplogroup D.
Identifiants
pubmed: 32565400
pii: S1567-7249(20)30040-4
doi: 10.1016/j.mito.2020.06.006
pii:
doi:
Substances chimiques
ADIPOQ protein, human
0
Adiponectin
0
DNA, Mitochondrial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
234-242Informations de copyright
Copyright © 2020 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.