INTREPID II: protocol for a multistudy programme of research on untreated psychosis in India, Nigeria and Trinidad.
epidemiology
mental health
schizophrenia & psychotic disorders
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
21 06 2020
21 06 2020
Historique:
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
16
2
2021
Statut:
epublish
Résumé
There are few robust and directly comparable studies of the epidemiology of psychotic disorders in the Global South. INTREPID II is designed to investigate variations in untreated psychotic disorders in the Global South in (1) incidence and presentation (2) 2-year course and outcome, (3) help-seeking and impact, and (4) physical health. INTREPID II is a programme of research incorporating incidence, case-control and cohort studies of psychoses in contiguous urban and rural areas in India, Nigeria and Trinidad. In each country, the target samples are 240 untreated cases with a psychotic disorder, 240 age-matched, sex-matched and neighbourhood-matched controls, and 240 relatives or caregivers. Participants will be followed, in the first instance, for 2 years. In each setting, we have developed and are employing comprehensive case-finding methods to ensure cohorts are representative of the target populations. Using methods developed during pilot work, extensive data are being collected at baseline and 2-year follow-up across several domains: clinical, social, help-seeking and impact, and biological. Informed consent is sought, and participants are free to withdraw from the study at any time. Participants are referred to mental health services if not already in contact with these and emergency treatment arranged where necessary. All data collected are confidential, except when a participant presents a serious risk to either themselves or others. This programme has been approved by ethical review boards at all participating centres. Findings will be disseminated through international conferences, publications in international journals, and through local events for key stakeholders.
Identifiants
pubmed: 32565481
pii: bmjopen-2020-039004
doi: 10.1136/bmjopen-2020-039004
pmc: PMC7311008
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e039004Subventions
Organisme : Wellcome Trust
ID : WT094525
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P025927/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/PO25927/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R010161/1
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: RMM has received payment for lectures from Janssen, Sunovian, Otsuka, Lundbeck, Angelini and Rekordati.
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