Protective Impacts of
Journal
Evidence-based complementary and alternative medicine : eCAM
ISSN: 1741-427X
Titre abrégé: Evid Based Complement Alternat Med
Pays: United States
ID NLM: 101215021
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
03
2020
revised:
14
04
2020
accepted:
06
05
2020
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
23
6
2020
Statut:
epublish
Résumé
The current study was aimed to examine the possible ameliorative impacts of MO leaf extract (MOLE) against MTX-induced alterations on oxidative stress of mouse spleen and explore the possible molecular mechanism that controls such impacts. Adult male mice were allocated into 4 groups: control, As compared with the MTX-injected group, MOLE effectively reduced the changes in total proteins, spleen MDA, SOD and catalase activities, and changes in serum antioxidants levels. Moreover, there is downregulation of antioxidant genes (SOD and catalase) and antiapoptotic genes (XIAP and Bcl-xl) along with upregulation in Bax and caspase-3 mRNA (apoptotic genes) in the MTX-injected group. MTX induced changes in IL-1 Current findings indicated that pretreatment with MOLE to MTX-intoxicated mice showed the potential usage of MO for oxidative stress and apoptosis treatment.
Identifiants
pubmed: 32565869
doi: 10.1155/2020/6738474
pmc: PMC7275960
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6738474Informations de copyright
Copyright © 2020 Mohamed Mohamed Soliman et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding the publication of this study.
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