Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants.
Adjuvants, Pharmaceutic
/ pharmacology
Antioxidants
/ pharmacology
Antiviral Agents
/ pharmacology
Ascorbic Acid
/ administration & dosage
Biomarkers
/ blood
Glutathione
/ blood
Hepacivirus
/ genetics
Hepatitis C, Chronic
/ blood
Humans
Liver Function Tests
Malondialdehyde
/ metabolism
Nigella sativa
/ chemistry
Oxidative Stress
/ drug effects
Ribavirin
/ therapeutic use
Sofosbuvir
/ therapeutic use
Superoxide Dismutase
/ metabolism
gamma-Glutamyltransferase
/ blood
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
02
2020
revised:
11
04
2020
accepted:
08
05
2020
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
28
1
2021
Statut:
epublish
Résumé
The widespread adaptation of a new generation of direct-acting antiviral agents (DAAs) unveils a superlative effect in the eradication of the hepatitis C virus (HCV). However, this therapy has been reported to exhibit vigorous side effects that pose a risk in fleet recovery. This study was conducted to investigate the efficacy of DAAs: sofosbuvir (SOF) and ribavirin (RBV), along with black cumin (BLC) and ascorbate (ASC), as adjuvants on hematological parameters; oxidative stress markers such as total antioxidant status (TAS), superoxide dismutase (SOD), reduced (GSH) and oxidized (GSSG) glutathione (GSH), gamma-glutamyl transferase (GGT), and malondialdehyde (MDA); liver function markers such as aspartate transaminase (AST), alanine aminotransferase (ALT), bilirubin, and alkaline phosphatase (ALP); and viral load with determined genotypes. HCV-infected patients (
Identifiants
pubmed: 32566096
doi: 10.1155/2020/7087921
pmc: PMC7290872
doi:
Substances chimiques
Adjuvants, Pharmaceutic
0
Antioxidants
0
Antiviral Agents
0
Biomarkers
0
Ribavirin
49717AWG6K
Malondialdehyde
4Y8F71G49Q
Superoxide Dismutase
EC 1.15.1.1
gamma-Glutamyltransferase
EC 2.3.2.2
Glutathione
GAN16C9B8O
Ascorbic Acid
PQ6CK8PD0R
Sofosbuvir
WJ6CA3ZU8B
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
7087921Informations de copyright
Copyright © 2020 Sarfraz Ahmed et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest regarding this study.
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