Post-transplant de-novo renal phospholipidosis in a kidney transplant recipient: Fabry disease or something else?
Fabry disease
cationic amphiphilic drugs
lamellar inclusions
myelin bodies
renal phospholipidosis
Journal
Clinical nephrology. Case studies
ISSN: 2196-5293
Titre abrégé: Clin Nephrol Case Stud
Pays: Germany
ID NLM: 101638685
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
02
2020
accepted:
09
04
2020
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
23
6
2020
Statut:
epublish
Résumé
Renal phospholipidosis is a rare cause of proteinuria and kidney dysfunction. We describe a kidney transplant recipient who presented with slowly rising serum creatinine, nephrotic range proteinuria, and lower extremity edema 10 years post transplant. He was diagnosed with renal phospholipidosis on the transplant kidney biopsy. Patient did not have prior history or current symptoms or signs of Fabry disease. Serum α-galactosidase level was normal. The etiology was suspected to be due to chronic use of sertraline, a previously reported cause of drug-induced renal phospholipidosis. Sertraline was discontinued, and proteinuria declined with stabilization of kidney function at 6-months follow-up.
Identifiants
pubmed: 32566446
doi: 10.5414/CNCS110131
pmc: PMC7303541
doi:
Types de publication
Case Reports
Langues
eng
Pagination
46-48Informations de copyright
© Dustri-Verlag Dr. K. Feistle.
Références
Clin J Am Soc Nephrol. 2010 Feb;5(2):379-85
pubmed: 20056752
Biochim Biophys Acta. 2013 Mar;1831(3):602-11
pubmed: 22960355
Exp Biol Med (Maywood). 2001 Oct;226(9):825-30
pubmed: 11568304
Am J Nephrol. 1983 Sep-Oct;3(5):279-84
pubmed: 6416069
NDT Plus. 2009 Dec;2(6):448-51
pubmed: 25949377