Thrombotic Risk in Cancer Patients: Diagnosis and Management of Venous Thromboembolism.
Cancer
direct oral anticoagulants
imaging
prevention
venous thromboembolism
Journal
Journal of cardiovascular echography
ISSN: 2211-4122
Titre abrégé: J Cardiovasc Echogr
Pays: India
ID NLM: 101562228
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
08
11
2019
revised:
28
11
2019
accepted:
05
12
2019
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
23
6
2020
Statut:
ppublish
Résumé
Venous thromboembolism (VTE) represents a major health problem, especially in cancer patients, who experience a significantly higher incidence of both deep vein thrombosis and pulmonary embolism compared to the general population. Indeed, patients with cancer have a prothrombotic state resulting in both increased expression of procoagulants and suppression of fibrinolytic activity. In addition, VTE increases the morbidity and mortality of these patients. For all these reasons, the prevention and treatment of VTE in cancer setting represent major challenges in daily practice. In general, low-molecular-weight heparin monotherapy is the standard of care for the management of cancer-associated VTE, as Vitamin K antagonists are less effective in this setting. Direct oral anticoagulants offer a potentially promising treatment option for cancer patients with VTE, since recent studies demonstrated their efficacy and safety also in this peculiar setting.
Identifiants
pubmed: 32566465
doi: 10.4103/jcecho.jcecho_63_19
pii: JCE-30-38
pmc: PMC7293865
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
S38-S44Informations de copyright
Copyright: © 2020 Journal of Cardiovascular Echography.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
J Thromb Haemost. 2015 Dec;13(12):2187-91
pubmed: 26407753
Blood. 2008 May 15;111(10):4902-7
pubmed: 18216292
Thromb Res. 2008;121(5):605-10
pubmed: 17692901
J Thromb Haemost. 2006 Mar;4(3):529-35
pubmed: 16460435
Eur J Vasc Endovasc Surg. 2009 Mar;37(3):349-56
pubmed: 19121589
JAMA. 2005 Feb 9;293(6):715-22
pubmed: 15701913
JAMA Intern Med. 2015 Jul;175(7):1112-7
pubmed: 25985219
Arch Intern Med. 2008 Nov 24;168(21):2377-81
pubmed: 19029504
Blood. 2015 Nov 19;126(21):2376-82
pubmed: 26585807
Thromb Haemost. 2017 Jan 26;117(2):219-230
pubmed: 27882374
Lancet Haematol. 2016 Aug;3(8):e379-87
pubmed: 27476789
Am J Cardiol. 1996 Aug 15;78(4):469-73
pubmed: 8752195
Front Cardiovasc Med. 2016 Jul 28;3:24
pubmed: 27517038
J Thorac Oncol. 2007 Aug;2(8):729-34
pubmed: 17762339
J Clin Oncol. 2018 Jul 10;36(20):2017-2023
pubmed: 29746227
Thromb Res. 2019 Jan;173:158-163
pubmed: 29506866
Arch Intern Med. 2002 Jun 10;162(11):1245-8
pubmed: 12038942
Lancet Haematol. 2014 Oct;1(1):e37-46
pubmed: 27030066
Chest. 2016 Feb;149(2):315-352
pubmed: 26867832
Blood. 2009 Aug 6;114(6):1138-9
pubmed: 19661277
Circulation. 2004 Mar 30;109(12 Suppl 1):I9-14
pubmed: 15051663
JAMA. 2006 Jan 11;295(2):199-207
pubmed: 16403932
Thromb Res. 2010 Apr;125 Suppl 2:S117-9
pubmed: 20433989
J Thromb Haemost. 2007 Mar;5(3):632-4
pubmed: 17319909
Br J Haematol. 2015 Sep;170(5):640-8
pubmed: 26114207
J Thromb Haemost. 2018 Sep;16(9):1891-1894
pubmed: 30027649
J Thromb Haemost. 2015 Jun;13(6):1028-35
pubmed: 25827941
J Thromb Haemost. 2013 Jan;11(1):56-70
pubmed: 23217107
Br J Cancer. 2008 Oct 7;99(7):1034-9
pubmed: 18781175
JAMA. 2005 Apr 27;293(16):2012-7
pubmed: 15855435
Thromb Res. 2015 Sep;136(3):582-9
pubmed: 26210891
Cancer. 2007 May 15;109(10):1989-95
pubmed: 17397035
J Clin Oncol. 2000 Sep;18(17):3078-83
pubmed: 10963635
Thromb Haemost. 2015 Jul;114(1):150-7
pubmed: 25739680
Arch Intern Med. 2006 Feb 27;166(4):458-64
pubmed: 16505267
J Oncol Pract. 2015 May;11(3):e442-4
pubmed: 25873061
Chest. 2008 Jun;133(6 Suppl):454S-545S
pubmed: 18574272
J Clin Oncol. 2013 Jun 10;31(17):2189-204
pubmed: 23669224
Best Pract Res Clin Haematol. 2012 Sep;25(3):235-42
pubmed: 22959540
Minerva Cardioangiol. 1998 Dec;46(12):507-14
pubmed: 10209941
Eur Respir J. 2019 Oct 9;54(3):
pubmed: 31473594
J Thromb Haemost. 2010 Jan;8(1):114-20
pubmed: 19889150
Ann Intern Med. 2012 Dec 4;157(11):796-807
pubmed: 22928173
J Thromb Haemost. 2012 May;10(5):807-14
pubmed: 22409262
J Clin Oncol. 2003 Oct 1;21(19):3665-75
pubmed: 14512399
Haematologica. 2004 Jul;89(7):826-31
pubmed: 15257934
Arch Intern Med. 2002 Aug 12-26;162(15):1729-35
pubmed: 12153376
J Natl Compr Canc Netw. 2018 Nov;16(11):1289-1303
pubmed: 30442731
Ann Intern Med. 2004 Apr 20;140(8):589-602
pubmed: 15096330
N Engl J Med. 2003 Jul 10;349(2):146-53
pubmed: 12853587
Clin Cancer Res. 2007 May 15;13(10):2870-5
pubmed: 17504985
J Neurosurg. 2007 Apr;106(4):601-8
pubmed: 17432710
Circulation. 2006 Jul 11;114(2):e28-32
pubmed: 16831989
Blood. 2014 Sep 18;124(12):1968-75
pubmed: 24963045