Cancer detection in excised breast tumors using terahertz imaging and spectroscopy.
Breast cancer
lumpectomy
margin assessment
terahertz imaging
terahertz spectroscopy
Journal
Biomedical spectroscopy and imaging
ISSN: 2212-8794
Titre abrégé: Biomed Spectrosc Imaging
Pays: Netherlands
ID NLM: 101592765
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
23
6
2020
pubmed:
1
1
2019
medline:
1
1
2019
Statut:
ppublish
Résumé
Terahertz imaging and spectroscopy has demonstrated a potential for differentiating tissue types of excised breast cancer tumors. Pulsed terahertz technology provides a broadband frequency range from 0.1 THz to 4 THz for detecting cancerous tissue. Tumor tissue types of interest include cancer typically manifested as infiltrating ductal or lobular carcinomas, fibro-glandular (healthy connective tissues) and fat. In this work, images of breast tumors excised from human and animal models are reviewed. In addition to alternate fresh tissues, breast cancer tissue phantoms are developed to further evaluate terahertz imaging and the potential use of contrast agents. Terahertz results are successfully validated with pathology images, showing strong differentiation between cancerous and healthy tissues for all freshly excised tissues and types. The advantages, challenges and limitations of THz imaging of breast cancer are discussed.
Identifiants
pubmed: 32566474
doi: 10.3233/bsi-190187
pmc: PMC7304303
mid: NIHMS1570119
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1-9Subventions
Organisme : NCI NIH HHS
ID : R15 CA208798
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest The authors have no conflict of interest to report.
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