Effect of nintedanib thermo-sensitive hydrogel on neovascularization in alkali burn rat model.
alkali burn
cornea
neovascularization
nintedanib
rat
Journal
International journal of ophthalmology
ISSN: 2222-3959
Titre abrégé: Int J Ophthalmol
Pays: China
ID NLM: 101553860
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
01
2020
accepted:
13
04
2020
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
23
6
2020
Statut:
epublish
Résumé
To investigate the effects of nintedanib thermo-sensitive hydrogel (NTH) on neovascularization and related markers in corneal alkali burns of Wistar rats. NTH was prepared by grinding, and its phase-transition temperature was determined. Thirty specific-pathogen-free Wistar rats served as a model of corneal alkali burn in the right eye were randomly divided into 3 groups ( The phase-transition temperature of nintedanib obtained by grinding was 37°C after adding artificial tears. The results of the alkali burn model indicated that the growth rate of neovascularization in the NTH group was slower than that in the model group, and the neovascularization area was significantly smaller than that in the model group ( NTH becomes colloidal at body temperature, which is beneficial for releasing the drug slowly and can significantly inhibit the neovascularization of corneal induced by alkali burn in rats.
Identifiants
pubmed: 32566497
doi: 10.18240/ijo.2020.06.04
pii: ijo-13-06-879
pmc: PMC7270255
doi:
Types de publication
Journal Article
Langues
eng
Pagination
879-885Informations de copyright
International Journal of Ophthalmology Press.
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