A follow-up study of children infected with SARS-CoV-2 from western China.
Coronavirus
asymptomatic infection
children
western China
Journal
Annals of translational medicine
ISSN: 2305-5839
Titre abrégé: Ann Transl Med
Pays: China
ID NLM: 101617978
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
23
6
2020
Statut:
ppublish
Résumé
To clarify the characteristic and the duration of positive nucleic acid in children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including asymptomatic children. A total of 32 children confirmed with SARS-CoV-2 infection between January 24 and February 12, 2020 from four provinces in western China were enrolled in this study and followed up until discharge and quarantine 14 days later. Eleven children (34%) were asymptomatic, among whom six children had normal computed tomographic (CT) scan images. Age and gender were not associated with clinical symptoms or the results of CT scan in children infected with SARS-CoV-2. The concentrations of white blood cells and neutrophils were higher in children with asymptomatic infection than in children with clinical symptoms or CT abnormalities. Patients who presented with CT abnormalities had lower D-dimer or lower total bilirubin than those who had normal CT scan but clinical symptoms. All children recovered and no one died or was admitted to the pediatric intensive care unit (PICU). The mean duration of positive SARS-CoV-2 nucleic acid was 15.4 (SD =7.2) days and similar for both asymptomatic children and children with symptoms or CT abnormalities. We found a significant negative correlation between the lymphocyte count and the duration of positive nucleic acid test. Children with asymptomatic infection should be quarantined for the same duration as symptomatic patients infected with SARS-CoV-2. The clinical significance and mechanism behind the negative correlation between the number of lymphocytes and the duration of positive SARS-CoV-2 needs further study.
Sections du résumé
BACKGROUND
BACKGROUND
To clarify the characteristic and the duration of positive nucleic acid in children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including asymptomatic children.
METHODS
METHODS
A total of 32 children confirmed with SARS-CoV-2 infection between January 24 and February 12, 2020 from four provinces in western China were enrolled in this study and followed up until discharge and quarantine 14 days later.
RESULTS
RESULTS
Eleven children (34%) were asymptomatic, among whom six children had normal computed tomographic (CT) scan images. Age and gender were not associated with clinical symptoms or the results of CT scan in children infected with SARS-CoV-2. The concentrations of white blood cells and neutrophils were higher in children with asymptomatic infection than in children with clinical symptoms or CT abnormalities. Patients who presented with CT abnormalities had lower D-dimer or lower total bilirubin than those who had normal CT scan but clinical symptoms. All children recovered and no one died or was admitted to the pediatric intensive care unit (PICU). The mean duration of positive SARS-CoV-2 nucleic acid was 15.4 (SD =7.2) days and similar for both asymptomatic children and children with symptoms or CT abnormalities. We found a significant negative correlation between the lymphocyte count and the duration of positive nucleic acid test.
CONCLUSIONS
CONCLUSIONS
Children with asymptomatic infection should be quarantined for the same duration as symptomatic patients infected with SARS-CoV-2. The clinical significance and mechanism behind the negative correlation between the number of lymphocytes and the duration of positive SARS-CoV-2 needs further study.
Identifiants
pubmed: 32566560
doi: 10.21037/atm-20-3192
pii: atm-08-10-623
pmc: PMC7290618
doi:
Types de publication
Journal Article
Langues
eng
Pagination
623Informations de copyright
2020 Annals of Translational Medicine. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-3192). The authors have no conflicts of interest to declare.
Références
Respirology. 2003 Nov;8 Suppl:S9-14
pubmed: 15018127
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Clin Infect Dis. 2020 Sep 12;71(6):1547-1551
pubmed: 32112072
N Engl J Med. 2020 Feb 27;382(9):872-874
pubmed: 31991079
N Engl J Med. 2020 Apr 23;382(17):1663-1665
pubmed: 32187458
JAMA. 2020 Feb 25;323(8):707-708
pubmed: 31971553
N Engl J Med. 2020 Mar 19;382(12):1177-1179
pubmed: 32074444
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
BMC Infect Dis. 2017 Sep 11;17(1):615
pubmed: 28893197
World J Pediatr. 2020 Jun;16(3):223-231
pubmed: 32034659
JAMA. 2020 Apr 21;323(15):1502-1503
pubmed: 32105304
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
JAMA. 2020 Feb 25;323(8):709-710
pubmed: 31999307
N Engl J Med. 2020 Apr 2;382(14):1370-1371
pubmed: 32163697
JAMA. 2020 Mar 17;323(11):1092-1093
pubmed: 32031568
Lancet. 2020 Feb 29;395(10225):689-697
pubmed: 32014114
BMJ. 2020 Mar 12;368:m1036
pubmed: 32165426
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
JAMA. 2020 Apr 7;323(13):1313-1314
pubmed: 32058570