A 2020 review on the role of procalcitonin in different clinical settings: an update conducted with the tools of the Evidence Based Laboratory Medicine.
Evidence Based Laboratory Medicine (EBLM)
Procalcitonin (PCT)
antibiotic therapy
Journal
Annals of translational medicine
ISSN: 2305-5839
Titre abrégé: Ann Transl Med
Pays: China
ID NLM: 101617978
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
23
6
2020
Statut:
ppublish
Résumé
Biomarkers to guide antibiotic treatment decisions have been proposed as an effective way to enhancing a more appropriate use of antibiotics. As a biomarker, procalcitonin (PCT) has been found to have good specificity to distinguish bacterial from non-bacterial inflammations. Decisions regarding antibiotic use in an individual patient are complex and should be based on the pre-test probability for bacterial infection, the severity of presentation and the results of PCT serum concentration. In the context of a high pre-test probability for bacterial infections and/or a high-risk patient with sepsis, monitoring of PCT over time helps to track the resolution of infection and decisions regarding early stop of antibiotic treatment. As outlined by the Evidence Based Laboratory Medicine (EBLM), not only the pre-test probability but also the positive likelihood ratio influence the performance of a test do be really diagnostic. This aspect should be taken into account in the interpretation of the results of clinical trials evaluating the performance of PCT in guiding antibiotic therapy.
Identifiants
pubmed: 32566636
doi: 10.21037/atm-20-1855
pii: atm-08-09-610
pmc: PMC7290560
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
610Informations de copyright
2020 Annals of Translational Medicine. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-1855). The series “Advances in Laboratory Tests for Infectious Diseases” was commissioned by the editorial office without any funding or sponsorship. The authors have no other conflicts of interest to declare.
Références
Crit Care Med. 2013 Oct;41(10):2336-43
pubmed: 23921272
Ann Emerg Med. 2007 Jul;50(1):34-41
pubmed: 17161501
J Burn Care Rehabil. 1999 Sep-Oct;20(5):354-60
pubmed: 10501320
J Med Microbiol. 2016 Aug;65(8):713-719
pubmed: 27170331
Am J Surg. 1980 Jul;140(1):144-50
pubmed: 7396078
Cell Biochem Biophys. 2015 May;72(1):259-63
pubmed: 25561281
J Clin Endocrinol Metab. 1994 Dec;79(6):1605-8
pubmed: 7989463
Shock. 2003 Nov;20(5):420-6
pubmed: 14560105
Crit Care Med. 2009 May;37(5):1642-8
pubmed: 19325491
Clin Biochem. 2015 Nov;48(16-17):1079-82
pubmed: 26129881
Indian J Pediatr. 2013 May;80(5):365-70
pubmed: 23334585
Cell Stress Chaperones. 2016 Jul;21(4):677-86
pubmed: 27137634
Crit Care. 2018 Nov 13;22(1):293
pubmed: 30424796
J Int Med Res. 2009 Nov-Dec;37(6):1709-17
pubmed: 20146868
Injury. 2007 Dec;38(12):1346-57
pubmed: 18048039
Surg Clin North Am. 1995 Apr;75(2):257-77
pubmed: 7899997
Cochrane Database Syst Rev. 2017 Apr 21;4:CD012645
pubmed: 28431197
Burns. 2007 Mar;33(2):189-94
pubmed: 17215085
Burns. 2014 Jun;40(4):664-9
pubmed: 24074718
Am J Respir Crit Care Med. 2006 Jul 1;174(1):84-93
pubmed: 16603606
Crit Care. 2006 Feb;10(1):R1
pubmed: 16356205
Crit Care Med. 2000 Jun;28(6):1828-32
pubmed: 10890628
Clin Microbiol Infect. 2018 Dec;24(12):1282-1289
pubmed: 29870855
PLoS One. 2012;7(2):e31126
pubmed: 22363564
Clin Chem Lab Med. 2016 Jan;54(1):163-8
pubmed: 26083268
Clin Biochem. 2006 Dec;39(12):1138-43
pubmed: 17052702
J Trauma. 1988 Jan;28(1):87-90
pubmed: 3339667
Int J Antimicrob Agents. 2015 Dec;46 Suppl 1:S19-24
pubmed: 26607343
Intensive Care Med. 2015 Oct;41(10):1739-51
pubmed: 26194026
Intensive Care Med. 2018 Apr;44(4):428-437
pubmed: 29663044
J Pediatr. 2006 Jul;149(1):72-6
pubmed: 16860131
Ann Intensive Care. 2016 Dec;6(1):51
pubmed: 27287669
Breathe (Sheff). 2019 Dec;15(4):296-304
pubmed: 31803264
Clin Chim Acta. 1999 Apr;282(1-2):175-83
pubmed: 10340446
J Lab Physicians. 2013 Jul;5(2):100-8
pubmed: 24701102
Curr Opin Pulm Med. 2019 Mar;25(2):158-164
pubmed: 30550505
Clin Respir J. 2018 Jan;12(1):10-15
pubmed: 27328801
Diagn Microbiol Infect Dis. 2016 May;85(1):109-15
pubmed: 26971636
Infect Chemother. 2013 Sep;45(3):308-14
pubmed: 24396632
Injury. 2012 Jan;43(1):91-5
pubmed: 21106197
Ann Intensive Care. 2016 Dec;6(1):59
pubmed: 27389015
Injury. 2013 Dec;44(12):1680-92
pubmed: 24119650
Anaesthesiol Intensive Ther. 2014 Apr-Jun;46(2):78-82
pubmed: 24858965
Ann Burns Fire Disasters. 2015 Jun 30;28(2):116-20
pubmed: 27252609
Lancet Infect Dis. 2016 Jul;16(7):819-827
pubmed: 26947523
Intern Emerg Med. 2017 Aug;12(5):629-635
pubmed: 28161884
Am J Emerg Med. 2007 Feb;25(2):179-84
pubmed: 17276808
Intensive Care Med. 1995 Apr;21(4):302-9
pubmed: 7650252
Pediatr Emerg Care. 2014 Nov;30(11):849-50
pubmed: 25373577
Minerva Anestesiol. 2006 Jan-Feb;72(1-2):69-80
pubmed: 16407808
Medicine (Baltimore). 2019 Aug;98(32):e16775
pubmed: 31393400
J Am Coll Surg. 2006 Mar;202(3):536-48
pubmed: 16500259
Burns Trauma. 2018 Oct 29;6:29
pubmed: 30397617
Infection. 2001 Aug;29(4):209-12
pubmed: 11545482
Int J Emerg Med. 2014 Feb 27;7(1):14
pubmed: 24576334
J Glob Infect Dis. 2011 Jan;3(1):14-8
pubmed: 21572603
Pediatr Int. 1999 Oct;41(5):496-9
pubmed: 10530060
J Burn Care Res. 2007 Nov-Dec;28(6):776-90
pubmed: 17925660
Crit Care Med. 2009 Jun;37(6):1845-9
pubmed: 19384224
Crit Care Med. 1999 Mar;27(3):498-504
pubmed: 10199528
Injury. 2009 Sep;40(9):907-11
pubmed: 19540488
Technol Health Care. 2010;18(2):89-100
pubmed: 20495248
Pharmacotherapy. 2015 Jun;35(6):631-48
pubmed: 26032691
Inflamm Res. 2002 May;51(5):265-72
pubmed: 12056515
J Gen Intern Med. 2002 Aug;17(8):646-9
pubmed: 12213147
Clin Biochem. 2015 Jan;48(1-2):50-4
pubmed: 25445228
Infect Dis (Lond). 2019 Sep;51(9):639-650
pubmed: 31355690
Burns Trauma. 2017 Aug 8;5:23
pubmed: 28795054
Chest. 2019 Jun;155(6):1109-1118
pubmed: 30772386
Clin Infect Dis. 1997 Jun;24(6):1240-2
pubmed: 9195090
Intensive Care Med. 2004 Feb;30(2):331-334
pubmed: 14727016
Crit Care Med. 2018 May;46(5):691-698
pubmed: 29271844
BMC Infect Dis. 2013 Apr 01;13:158
pubmed: 23547790
Clin Biochem. 2008 Oct;41(14-15):1150-5
pubmed: 18606160
Crit Care. 2018 Aug 15;22(1):191
pubmed: 30111341
Saudi Med J. 2006 Apr;27(4):560-2
pubmed: 16598344
Int J Chron Obstruct Pulmon Dis. 2012;7:127-35
pubmed: 22399852
Scand J Infect Dis. 2007;39(6-7):542-53
pubmed: 17577816
Intensive Care Med. 2000 Mar;26 Suppl 2:S159-64
pubmed: 18470712
Clin Chem Lab Med. 2015 Mar;53(4):583-92
pubmed: 25581762
Crit Care. 2013 Dec 11;17(6):R291
pubmed: 24330744
Respiration. 2016;91(4):316-24
pubmed: 27081845
JAMA. 2013 Feb 20;309(7):717-8
pubmed: 23423417
Int J Chron Obstruct Pulmon Dis. 2015 Apr 13;10:767-74
pubmed: 25926728
Burns. 2017 Nov;43(7):1427-1434
pubmed: 28454850
Neurologia. 2016 Jan-Feb;31(1):9-17
pubmed: 25288535
Burns. 2008 Sep;34(6):770-4
pubmed: 18513877
Pak J Med Sci. 2017 May-Jun;33(3):566-569
pubmed: 28811772
Burns. 2011 Jun;37(4):549-58
pubmed: 20537467
J Infect Chemother. 2012 Dec;18(6):891-7
pubmed: 22692596
Burns. 2013 Jun;39(4):583-8
pubmed: 23137628
World J Surg. 2009 Mar;33(3):558-66
pubmed: 19148699
Crit Care. 2016 Jul 07;20(1):180
pubmed: 27384242
Wien Klin Wochenschr. 2015 Oct;127(19-20):756-63
pubmed: 25586444
Medicine (Baltimore). 2017 Sep;96(35):e7637
pubmed: 28858084
J Pak Med Assoc. 2011 Apr;61(4):346-51
pubmed: 21465970
Eur J Clin Microbiol Infect Dis. 2006 Aug;25(8):501-9
pubmed: 16896823
Shock. 2013 Nov;40(5):382-6
pubmed: 23903853
Eur J Clin Microbiol Infect Dis. 2004 Feb;23(2):136-8
pubmed: 14689316
Burns. 2019 Feb;45(1):16-31
pubmed: 29802006
Medicine (Baltimore). 2017 Jul;96(30):e7487
pubmed: 28746189
Surgery. 2009 Jul;146(1):72-81
pubmed: 19541012
Infez Med. 2015 Sep;23(3):230-7
pubmed: 26397291
Am J Med Sci. 2019 Jul;358(1):33-44
pubmed: 31084909
Curr Opin Pulm Med. 2019 Mar;25(2):150-157
pubmed: 30418243
OMICS. 2017 Apr;21(4):232-243
pubmed: 28388301
Crit Care. 2011;15(3):R136
pubmed: 21645387
Neonatology. 2012;102(1):25-36
pubmed: 22507868
Crit Care Med. 2011 Sep;39(9):2048-58
pubmed: 21572328
Int J Infect Dis. 2019 Aug;85:158-166
pubmed: 31229612
Lancet. 2010 Feb 6;375(9713):463-74
pubmed: 20097417
Surg Infect (Larchmt). 2018 Feb/Mar;19(2):168-175
pubmed: 29327977
Mediators Inflamm. 2013;2013:969875
pubmed: 23935252
Crit Care. 2005 Aug;9(4):R344-50
pubmed: 16137346
J Clin Epidemiol. 2003 Nov;56(11):1129-35
pubmed: 14615004
Neurosciences (Riyadh). 2008 Jan;13(1):91-2
pubmed: 21063298
Eur Respir Rev. 2017 Jan 31;26(143):
pubmed: 28143877
PLoS One. 2015 Mar 11;10(3):e0118241
pubmed: 25760346
J Trauma Acute Care Surg. 2012 Aug;73(2):413-8; discussion 418
pubmed: 22846948
PLoS One. 2016 Dec 22;11(12):e0168475
pubmed: 28005932
Arch Pediatr Adolesc Med. 2008 Dec;162(12):1157-63
pubmed: 19047543
World J Emerg Surg. 2019 Jun 13;14:27
pubmed: 31210778
Lancet Infect Dis. 2007 Mar;7(3):210-7
pubmed: 17317602
Crit Care Med. 2000 Apr;28(4):950-7
pubmed: 10809265
Crit Care. 2019 Dec 3;23(1):390
pubmed: 31796098
Lancet. 2005 Apr 23-29;365(9469):1500-5
pubmed: 15850636
Crit Care Med. 1992 Jun;20(6):864-74
pubmed: 1597042
J Clin Lab Anal. 2015 May;29(3):169-74
pubmed: 24797775
Int J Infect Dis. 2015 Sep;38:68-76
pubmed: 26188130
J Trauma. 2000 May;48(5):932-7
pubmed: 10823539
Exp Ther Med. 2017 Jul;14(1):193-198
pubmed: 28672914
Medicine (Baltimore). 2016 Mar;95(11):e3079
pubmed: 26986140
Am J Med. 1996 Jan;100(1):78-84
pubmed: 8579091
J Clin Med Res. 2018 Jul;10(7):545-551
pubmed: 29904438
Am J Respir Crit Care Med. 2014 Nov 15;190(10):1102-10
pubmed: 25295709
Intensive Care Med. 1998 Feb;24(2):185-8
pubmed: 9539079
Clin Infect Dis. 2004 Jul 15;39(2):206-17
pubmed: 15307030
J Med Econ. 2015;18(11):944-53
pubmed: 26105574
Clin Chim Acta. 2016 Sep 1;460:93-101
pubmed: 27353646
Ann Surg. 2014 Jul;260(1):13-21
pubmed: 24651132
Diagn Microbiol Infect Dis. 2016 Feb;84(2):175-80
pubmed: 26586579
J Trauma. 2009 Jan;66(1):243-9
pubmed: 19131834
Iran J Pediatr. 2014 Dec;24(6):739-44
pubmed: 26019780
Diagn Microbiol Infect Dis. 2012 May;73(1):27-30
pubmed: 22494555
Burns. 2007 Nov;33(7):860-4
pubmed: 17532575
Ann Clin Lab Sci. 2012 Winter;42(1):57-64
pubmed: 22371911
Clin Infect Dis. 2020 Jan 16;70(3):538-542
pubmed: 31241140
Clin Infect Dis. 1999 Jun;28(6):1313-6
pubmed: 10451174
J Infect Public Health. 2014 Mar-Apr;7(2):106-13
pubmed: 24238573
Arch Intern Med. 2008 Oct 13;168(18):2000-7; discussion 2007-8
pubmed: 18852401
J Leukoc Biol. 2007 Jan;81(1):1-5
pubmed: 17032697
Shock. 2016 Sep;46(3):254-60
pubmed: 27172160
J Burn Care Rehabil. 2004 Jan-Feb;25(1):76-80
pubmed: 14726743
N Engl J Med. 2018 Jul 19;379(3):236-249
pubmed: 29781385
Pancreatology. 2013 Jul-Aug;13(4 Suppl 2):e1-15
pubmed: 24054878
Scand J Infect Dis. 1993;25(5):625-30
pubmed: 8284648
Surg Today. 2020 Feb;50(2):87-96
pubmed: 30993454
Burns. 1998 Dec;24(8):745-50
pubmed: 9915676
Injury. 2003 Jun;34(6):397-404
pubmed: 12767787
Cochrane Database Syst Rev. 2017 Oct 12;10:CD007498
pubmed: 29025194
J Pediatr. 1988 Oct;113(4):641-6
pubmed: 3262735
J Intensive Care. 2019 Apr 15;7:22
pubmed: 31016020
J Korean Med Sci. 2019 Apr 15;34(14):e110
pubmed: 30977312