Neuroprotective Effect of Brazilin on Amyloid β (25-35)-Induced Pathology in a Human Neuroblastoma Model.


Journal

ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658

Informations de publication

Date de publication:
16 Jun 2020
Historique:
received: 02 03 2020
accepted: 18 05 2020
entrez: 23 6 2020
pubmed: 23 6 2020
medline: 23 6 2020
Statut: epublish

Résumé

Until the recent past, the sole exemplar of proteins as infectious agents leading to neurodegenerative disorders remained the prion protein. Since then, the self-seeding mechanism characteristic of the prion protein has also been attributed to other neurodegenerative-disease-associated proteins, including amyloid-β (Aβ), tau, and α-synuclein (α-Syn). In model cell line studies, truncated Aβ, viz. amyloid beta (25-35), has been found to influence cellular homeostasis through its interactions with, and via, the disruption of key housekeeping machinery. Here, we demonstrate that the incubation of human neuroblastoma (SH-SY5Y) cell line with Brazilin ((6

Identifiants

pubmed: 32566844
doi: 10.1021/acsomega.0c00396
pmc: PMC7301549
doi:

Types de publication

Journal Article

Langues

eng

Pagination

13785-13792

Informations de copyright

Copyright © 2020 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Gabriela Henríquez (G)

Department of Environmental Science & Engineering, The University of Texas at El Paso (UTEP), El Paso, Texas 79968, United States.

Lois Mendez (L)

Department of Chemistry and Biochemistry, The University of Texas at El Paso (UTEP), El Paso, Texas 79968, United States.

Armando Varela-Ramirez (A)

Department of Biological Sciences, Bioscience Research Building, Border Biomedical Research Center, the Cellular Characterization and Biorepository Core Facility, The University of Texas at El Paso (UTEP), El Paso, Texas 79968, United States.

Erick Guerrero (E)

Department of Chemistry and Biochemistry, The University of Texas at El Paso (UTEP), El Paso, Texas 79968, United States.

Mahesh Narayan (M)

Department of Chemistry and Biochemistry, The University of Texas at El Paso (UTEP), El Paso, Texas 79968, United States.

Classifications MeSH