Role of Adenosine in Epilepsy and Seizures.
adenosine
adenosine kinase
adenosine receptors
epilepsy
epileptogenesis
seizure
Journal
Journal of caffeine and adenosine research
ISSN: 2573-3400
Titre abrégé: J Caffeine Adenosine Res
Pays: United States
ID NLM: 101726580
Informations de publication
Date de publication:
01 Jun 2020
01 Jun 2020
Historique:
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
23
6
2020
Statut:
ppublish
Résumé
Adenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure activity produces large quantities of adenosine, and it is this seizure-induced adenosine surge that normally stops a seizure. However, within the context of epilepsy, adenosine plays a wide spectrum of different roles. It not only controls seizures (ictogenesis), but also plays a major role in processes that turn a normal brain into an epileptic brain (epileptogenesis). It is involved in the control of abnormal synaptic plasticity and neurodegeneration and plays a major role in the expression of comorbid symptoms and complications of epilepsy, such as sudden unexpected death in epilepsy (SUDEP). Given the important role of adenosine in epilepsy, therapeutic strategies are in development with the goal to utilize adenosine augmentation not only for the suppression of seizures but also for disease modification and epilepsy prevention, as well as strategies to block adenosine A
Identifiants
pubmed: 32566903
doi: 10.1089/caff.2019.0022
pii: 10.1089/caff.2019.0022
pmc: PMC7301316
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
45-60Subventions
Organisme : NINDS NIH HHS
ID : R01 NS065957
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103740
Pays : United States
Informations de copyright
Copyright 2020, Mary Ann Liebert, Inc., publishers.
Déclaration de conflit d'intérêts
No competing financial interests exist.
Références
J Med Chem. 2000 Jul 27;43(15):2883-93
pubmed: 10956196
Brain Res. 1990 Dec 10;535(2):195-204
pubmed: 1705855
J Neurosci. 2004 Jan 21;24(3):692-701
pubmed: 14736855
Glia. 2003 Nov;44(2):166-72
pubmed: 14515332
J Neurophysiol. 2000 Apr;83(4):1787-95
pubmed: 10758091
Eur J Pharmacol. 1995 Feb 24;275(1):23-9
pubmed: 7774659
Nat Commun. 2016 Jun 17;7:11915
pubmed: 27312972
Neurobiol Aging. 2006 Feb;27(2):351-60
pubmed: 16399217
Neuron. 1994 May;12(5):1139-48
pubmed: 8185949
Trends Neurosci. 2013 Mar;36(3):174-84
pubmed: 23298414
Curr Neuropharmacol. 2009 Sep;7(3):257-68
pubmed: 20190967
Eur J Neurosci. 2003 Aug;18(4):820-8
pubmed: 12925008
Neurobiol Aging. 2008 Oct;29(10):1597-601
pubmed: 17481781
Eur J Pharmacol. 1999 Apr 29;371(2-3):137-45
pubmed: 10357250
Neuron. 1992 Nov;9(5):919-27
pubmed: 1358131
Front Cell Neurosci. 2019 May 29;13:242
pubmed: 31191257
J Neurosci. 1997 Jan 15;17(2):607-14
pubmed: 8987783
Can J Physiol Pharmacol. 1974 Dec;52(6):1226-9
pubmed: 4451894
Epilepsy Res. 2018 Jan;139:73-79
pubmed: 29197668
Curr Med Chem. 2001 Sep;8(11):1275-89
pubmed: 11562266
J Neurosci. 2017 Feb 8;37(6):1439-1452
pubmed: 28028196
Lancet Neurol. 2016 Sep;15(10):1075-88
pubmed: 27571159
J Cereb Blood Flow Metab. 2006 Apr;26(4):565-75
pubmed: 16121125
Neurology. 2013 Apr 23;80(17):1571-6
pubmed: 23535492
PLoS One. 2011 Feb 28;6(2):e17338
pubmed: 21386999
Epilepsy Behav. 2019 Oct;99:106478
pubmed: 31481308
J Neurosci. 1991 May;11(5):1375-80
pubmed: 1851219
J Caffeine Adenosine Res. 2019 Sep 1;9(3):104-127
pubmed: 31559391
Mol Psychiatry. 2016 Jan;21(1):97-107
pubmed: 25450226
Nat Rev Neurosci. 2006 Jan;7(1):30-40
pubmed: 16371948
Brain Res. 1986 Jun 25;376(2):382-6
pubmed: 3015342
Epilepsy Behav. 2015 Jul;48:15-20
pubmed: 26037844
J Comp Neurol. 1991 Jun 15;308(3):381-96
pubmed: 1865007
J Neurosci. 2009 Nov 25;29(47):14741-51
pubmed: 19940169
Brain Res. 1998 Jan 26;782(1-2):240-7
pubmed: 9519269
Brain Res. 2000 Jul 28;872(1-2):44-53
pubmed: 10924674
Neuroreport. 1995 May 30;6(8):1097-100
pubmed: 7662885
Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15927-31
pubmed: 19721003
Molecules. 2017 Apr 23;22(4):
pubmed: 28441750
Expert Opin Investig Drugs. 2000 Mar;9(3):551-64
pubmed: 11060695
Neuropharmacology. 2020 May 1;167:107741
pubmed: 31419398
Eur Neuropsychopharmacol. 2004 Oct;14(5):407-12
pubmed: 15336302
J Neurosci. 2006 May 17;26(20):5370-82
pubmed: 16707789
Epileptic Disord. 2003 May;5 Suppl 1:S9-16
pubmed: 12915336
Biochem J. 1978 Sep 15;174(3):965-77
pubmed: 215126
J Neurosci. 1997 Jul 1;17(13):4956-64
pubmed: 9185533
Exp Neurol. 2006 Jul;200(1):184-90
pubmed: 16750195
Ann Neurol. 1992 Nov;32(5):618-24
pubmed: 1449242
Neurochem Res. 2019 Apr;44(4):787-795
pubmed: 30610653
Epilepsia. 2010 Mar;51(3):465-8
pubmed: 19674057
Neuropharmacology. 2009 Feb;56(2):429-37
pubmed: 18957298
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Brain Res. 2003 Oct 10;987(1):49-58
pubmed: 14499945
J Physiol Sci. 2017 Jan;67(1):45-62
pubmed: 27535569
J Neurophysiol. 2003 Aug;90(2):1295-303
pubmed: 12904509
Neurochem Int. 2001 Feb;38(2):107-25
pubmed: 11137880
J Neurosci Res. 2004 Dec 1;78(5):742-8
pubmed: 15470722
Methods Mol Biol. 2017;1622:225-239
pubmed: 28674812
Epilepsia. 2005;46 Suppl 5:166-73
pubmed: 15987273
Epilepsia. 2005 Aug;46(8):1162-9
pubmed: 16060924
Neuropharmacology. 2015 Oct;97:18-34
pubmed: 25979489
Epilepsy Res. 2012 Jul;100(3):229-38
pubmed: 21880467
Epilepsia. 2016 Jan;57 Suppl 1:35-45
pubmed: 26749015
Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7833-8
pubmed: 26056314
Brain Res Mol Brain Res. 2004 Jun 18;125(1-2):76-85
pubmed: 15193424
Br J Pharmacol. 2019 Sep;176(18):3666-3680
pubmed: 31220343
J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):211-3
pubmed: 10644790
Exp Neurol. 2007 Nov;208(1):26-37
pubmed: 17716659
Nat Neurosci. 2015 Mar;18(3):423-34
pubmed: 25622143
Epilepsia. 2019 Mar;60(3):508-517
pubmed: 30756391
Front Mol Neurosci. 2016 Apr 13;9:26
pubmed: 27147960
Epilepsy Behav. 2009 Feb;14(2):280-7
pubmed: 19130900
J Physiol. 1986 Jan;370:75-90
pubmed: 2420981
J Med Chem. 2014 May 8;57(9):3623-50
pubmed: 24164628
Brain Res. 1995 Jun 26;684(1):103-6
pubmed: 7583197
JAMA Neurol. 2018 Nov 1;75(11):1375-1382
pubmed: 30039175
Eur J Neurosci. 2004 May;19(9):2539-50
pubmed: 15128407
J Cereb Blood Flow Metab. 2012 Jul;32(7):1152-66
pubmed: 22027938
Cephalalgia. 2007 Feb;27(2):177-81
pubmed: 17257240
Epilepsia. 2007 Jan;48(1):43-58
pubmed: 17241207
J Med Chem. 2000 Jul 27;43(15):2894-905
pubmed: 10956197
Epilepsy Behav. 2017 Jul;72:188-194
pubmed: 28647441
Neurobiol Aging. 2009 Nov;30(11):1877-84
pubmed: 18304697
Epilepsy Curr. 2012 May;12(3):111-2
pubmed: 22688854
J Clin Invest. 2008 Feb;118(2):571-82
pubmed: 18172552
Dialogues Clin Neurosci. 2014 Sep;16(3):273-5
pubmed: 25364279
Neuroreport. 1999 Nov 26;10(17):3535-41
pubmed: 10619640
Neuropharmacology. 2015 Dec;99:500-9
pubmed: 26256422
Brain Res Bull. 2019 Sep;151:65-73
pubmed: 30660718
J Neurochem. 2001 Jan;76(2):372-82
pubmed: 11208900
Nat Neurosci. 2009 Jul;12(7):872-8
pubmed: 19525944
J Neuropathol Exp Neurol. 2009 Apr;68(4):356-64
pubmed: 19287316
Neuropharmacology. 2008 Jul;55(1):35-40
pubmed: 18486156
J Neurosci. 2008 Mar 19;28(12):2970-5
pubmed: 18354001
Purinergic Signal. 2016 Jun;12(2):295-302
pubmed: 26939579
Neuropharmacology. 2001 Mar;40(3):424-32
pubmed: 11166335
Nat Rev Neurosci. 2019 May;20(5):282-297
pubmed: 30792501
J Neurochem. 2011 Apr;117(1):100-11
pubmed: 21235574
Eur J Neurosci. 2009 Sep;30(6):1023-35
pubmed: 19723291
Epilepsia. 2012 Jan;53(1):177-88
pubmed: 22150479
Front Mol Neurosci. 2018 Jul 12;11:235
pubmed: 30050407
Epilepsia. 1980 Oct;21(5):541-8
pubmed: 7418669
Epilepsia. 2013 Aug;54 Suppl 4:35-43
pubmed: 23909852
Exp Neurol. 2013 Jun;244:11-21
pubmed: 21985866
Neuron. 2003 Dec 4;40(5):971-82
pubmed: 14659095
Epilepsy Res. 2006 Jan;68 Suppl 1:S39-48
pubmed: 16384689
Front Psychiatry. 2014 Jun 13;5:67
pubmed: 24982640
Exp Neurol. 2009 Sep;219(1):126-35
pubmed: 19460372
Epilepsy Res. 2019 Mar;151:48-66
pubmed: 30831337
J Neurochem. 2010 Jan;112(2):453-62
pubmed: 19878534
Neurobiol Dis. 2018 Sep;117:72-81
pubmed: 29859867
Cereb Cortex. 2016 Mar;26(3):1081-95
pubmed: 25452570
Neurosci Lett. 1997 Nov 28;238(1-2):73-7
pubmed: 9464658
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15118-23
pubmed: 18809912
Neuroscience. 1999;93(2):519-26
pubmed: 10465435
Cold Spring Harb Perspect Med. 2015 Mar 02;5(3):a022434
pubmed: 25732035
Front Neurol. 2019 Feb 26;10:119
pubmed: 30863356
Oncotarget. 2018 Jun 1;9(42):26954-26976
pubmed: 29928494
Epilepsia. 2005;46 Suppl 5:159-65
pubmed: 15987272
Science. 2005 Oct 7;310(5745):113-6
pubmed: 16210541
Lancet Neurol. 2013 Oct;12(10):966-77
pubmed: 24012372
Neurotherapeutics. 2009 Apr;6(2):278-83
pubmed: 19332320
Brain Behav. 2018 Apr 17;8(5):e00952
pubmed: 29761007
Epilepsy Behav. 2018 Sep;86:173-178
pubmed: 30017837
Lancet Neurol. 2013 Jun;12(6):563-71
pubmed: 23642342
Epilepsy Res. 2004 Apr-May;59(2-3):83-94
pubmed: 15246113
Nat Rev Neurosci. 2004 Feb;5(2):146-56
pubmed: 14735117
Naunyn Schmiedebergs Arch Pharmacol. 2007 Apr;375(2):133-44
pubmed: 17310264
Synapse. 1989;3(2):154-71
pubmed: 2648633
Neuroscience. 2006 Sep 29;142(1):125-37
pubmed: 16859834
Glia. 2012 Jan;60(1):83-95
pubmed: 21964979
Pharmacol Res. 2007 Aug;56(2):110-7
pubmed: 17548208
Epilepsia. 2011 Mar;52(3):589-601
pubmed: 21275977
Br J Pharmacol. 2000 Dec;131(8):1629-34
pubmed: 11139440
Mol Psychiatry. 2015 Nov;20(11):1481
pubmed: 25802981
J Cereb Blood Flow Metab. 2003 Feb;23(2):137-49
pubmed: 12571445
Epilepsy Res Suppl. 1996;12:343-54
pubmed: 9302534
Ann Neurol. 2008 Mar;63(3):338-46
pubmed: 18300283
Neurobiol Aging. 2007 Dec;28(12):1914-24
pubmed: 16996650
Front Cell Neurosci. 2014 Aug 04;8:211
pubmed: 25136294
J Neurochem. 2016 Dec;139(6):1019-1055
pubmed: 27365148
Neuroscience. 2016 May 26;323:157-69
pubmed: 25592426
J Pharmacol Exp Ther. 1993 Mar;264(3):1415-24
pubmed: 8450475
Br J Pharmacol. 2005 Mar;144(5):642-50
pubmed: 15678095
Glia. 2018 Jun;66(6):1235-1243
pubmed: 29044647
Lancet. 2005 Jun 11-17;365(9476):1985-6
pubmed: 15950700
Brain. 2007 May;130(Pt 5):1276-88
pubmed: 17472985
Neuroreport. 1995 Jul 31;6(11):1583-8
pubmed: 7579154
Purinergic Signal. 2016 Dec;12(4):719-734
pubmed: 27650530
Eur J Pharmacol. 1995 Dec 29;294(2-3):383-9
pubmed: 8750698
J Neurosci. 2013 Jul 10;33(28):11390-9
pubmed: 23843511
Neurosci Lett. 2011 Jun 27;497(3):240-6
pubmed: 21458536
Neurobiol Dis. 2019 Dec;132:104570
pubmed: 31394204
Acta Neuropathol. 2013 Nov;126(5):741-56
pubmed: 24005891
Epilepsia. 1997 Nov;38(11 Suppl):S26-9
pubmed: 19909319
Neuropharmacology. 2020 May 1;167:107605
pubmed: 30980836
Pharmacol Rev. 2010 Dec;62(4):668-700
pubmed: 21079040
Neuropharmacology. 2016 May;104:131-9
pubmed: 26341819
Eur J Pharmacol. 1994 Apr 1;255(1-3):239-43
pubmed: 8026549
Bioorg Med Chem Lett. 2001 Aug 20;11(16):2071-4
pubmed: 11514141
J Pharmacol Exp Ther. 1982 Jan;220(1):70-6
pubmed: 7053424
Nat Genet. 1997 Aug;16(4):387-90
pubmed: 9241279
Biol Psychiatry. 2015 Dec 1;78(11):763-74
pubmed: 25869810
Science. 2008 Dec 5;322(5907):1551-5
pubmed: 19056987
Epilepsia. 2003 Jul;44(7):877-85
pubmed: 12823569
Epilepsy Res Treat. 2014;2014:404202
pubmed: 24627806
Neuroscience. 1998 Jul;85(1):229-37
pubmed: 9607714
Glia. 2012 Aug;60(8):1234-43
pubmed: 22700220
Handb Exp Pharmacol. 2019;253:359-381
pubmed: 28646346
Int Rev Neurobiol. 2007;81:85-110
pubmed: 17433919
Lancet Neurol. 2008 Jun;7(6):500-6
pubmed: 18456557
Neuropharmacology. 2013 Jun;69:3-15
pubmed: 22342985
Neuroscience. 1987 Jun;21(3):869-75
pubmed: 3627439
J Neurol Neurosurg Psychiatry. 1996 Mar;60(3):297-300
pubmed: 8609507
Seizure. 2015 Feb;25:72-9
pubmed: 25645641
Neuropharmacology. 1994 Sep;33(9):1049-53
pubmed: 7838317
Epilepsia. 2011 Jul;52 Suppl 4:15-9
pubmed: 21732935
Brain Res. 1996 Feb 26;710(1-2):56-68
pubmed: 8963679
Eur J Neurosci. 2011 Jul;34(1):12-21
pubmed: 21615561
Trends Mol Med. 2007 Feb;13(2):54-63
pubmed: 17207662
Epilepsia. 1984 Dec;25(6):729-40
pubmed: 6510381
Brain Res. 1994 Jun 27;649(1-2):208-16
pubmed: 7953635
Epilepsy Behav. 2010 Apr;17(4):436-40
pubmed: 20335075
Epilepsia. 2008;49 Suppl 2:42-52
pubmed: 18226171
PLoS One. 2013 Nov 28;8(11):e80902
pubmed: 24312250
eNeuro. 2018 Dec 26;5(6):
pubmed: 30627646
Neuron Glia Biol. 2008 May;4(2):91-9
pubmed: 19674507
Neuron. 1992 Jun;8(6):1139-50
pubmed: 1351733
Naunyn Schmiedebergs Arch Pharmacol. 2009 Sep;380(3):223-32
pubmed: 19488739
Epilepsy Res. 2012 Jun;100(1-2):157-67
pubmed: 22401823
Neuroreport. 1996 Apr 10;7(5):1029-35
pubmed: 8804045
Acta Neurol Scand. 2019 Mar;139(3):220-230
pubmed: 30443951
Neurochem Int. 1996 Jul;29(1):37-42
pubmed: 8808787
J Clin Invest. 2011 Jul;121(7):2679-83
pubmed: 21701065
Biomark Med. 2011 Oct;5(5):607-14
pubmed: 22003909
Cold Spring Harb Perspect Med. 2015 Sep 18;5(10):
pubmed: 26385090
Epilepsia. 2011 Sep;52(9):1645-55
pubmed: 21635241
Int Rev Neurobiol. 2014;114:155-85
pubmed: 25078502
Seizure. 2006 Jan;15(1):41-8
pubmed: 16337818
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7611-6
pubmed: 11404469
J Epilepsy Res. 2019 Jun 30;9(1):27-35
pubmed: 31482054
Int Rev Neurobiol. 2005;63:191-270
pubmed: 15797469
Brain. 2019 Nov 1;142(11):3636-3654
pubmed: 31599329
J Neurochem. 2016 Dec;139(6):1056-1070
pubmed: 27778347
Neuroscientist. 2018 Apr;24(2):186-200
pubmed: 28468530
J Feline Med Surg. 2016 Apr;18(4):328-36
pubmed: 25916687
Neurochem Res. 2017 Jul;42(7):1919-1925
pubmed: 28332054
J Neurosci. 2015 Feb 25;35(8):3330-45
pubmed: 25716834
J Neurosci. 2016 Nov 30;36(48):12117-12128
pubmed: 27903722
Neuroscience. 2001;102(1):23-34
pubmed: 11226667
Neurosci Lett. 1991 Jan 14;122(1):50-2
pubmed: 1676145
Pharmacol Rev. 2011 Mar;63(1):1-34
pubmed: 21303899
Sci Transl Med. 2013 Aug 7;5(197):197ra104
pubmed: 23926202
J Neurosci. 2012 Feb 1;32(5):1577-88
pubmed: 22302800
Curr Pharm Des. 1998 Oct;4(5):403-16
pubmed: 10197052
Neurobiol Aging. 1991 Sep-Oct;12(5):523-30
pubmed: 1770988
Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8586-90
pubmed: 1382294
Behav Brain Res. 2017 Mar 15;321:8-17
pubmed: 28007538
J Clin Invest. 2013 Aug;123(8):3552-63
pubmed: 23863710
Neuroscience. 1993 Dec;57(3):565-75
pubmed: 8309525
Epilepsy Res. 2000 May;39(3):229-38
pubmed: 10771249
PLoS Biol. 2019 Apr 5;17(4):e3000213
pubmed: 30951527
Neuropharmacology. 2004 Sep;47(3):427-37
pubmed: 15275832
Epilepsia. 2014 Apr;55(4):475-82
pubmed: 24730690
J Huazhong Univ Sci Technolog Med Sci. 2012 Apr;32(2):257-264
pubmed: 22528231
Epilepsia. 2012 Dec;53 Suppl 9:11-20
pubmed: 23216575
Neuroscience. 2006;138(4):1195-203
pubmed: 16442739
J Neurochem. 1999 Oct;73(4):1733-8
pubmed: 10501222
Epilepsia. 2011 Apr;52(4):657-78
pubmed: 21426333
Mol Psychiatry. 2018 Jun 27;:
pubmed: 29950682
Lancet. 2019 Feb 16;393(10172):689-701
pubmed: 30686584
Int J Mol Sci. 2014 Jan 28;15(2):2024-52
pubmed: 24477263
Neurosci Lett. 2000 Apr 21;284(1-2):49-52
pubmed: 10771159
Neurosci Lett. 1989 Dec 4;106(3):287-93
pubmed: 2532311
Seizure. 2017 Oct;51:1-5
pubmed: 28743048
Epilepsia. 2018 Jan;59(1):37-66
pubmed: 29247482
Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1519-1538
pubmed: 28179120
Front Neurol. 2017 Jul 20;8:348
pubmed: 28775708
Neuroscience. 2005;132(4):893-903
pubmed: 15857695
Epilepsia. 2019 Apr;60(4):615-625
pubmed: 30815855
J Headache Pain. 2018 May 25;19(1):41
pubmed: 29802484
Neuropharmacology. 2019 Jan;144:122-132
pubmed: 30336152
Proc Natl Acad Sci U S A. 2002 May 14;99(10):6985-90
pubmed: 11997462
Pharmacol Rev. 2013 Apr 16;65(3):906-43
pubmed: 23592612
Curr Top Med Chem. 2005;5(1):43-58
pubmed: 15638777
Br J Pharmacol. 2015 Aug;172(15):3831-45
pubmed: 25939452
Epilepsy Res. 2017 Nov;137:56-60
pubmed: 28941835
Exp Neurol. 2005 May;193(1):53-64
pubmed: 15817264
Life Sci. 1993;53(10):755-63
pubmed: 8355564
Neuroreport. 1992 Sep;3(9):735-7
pubmed: 1421127