nCOV-19 peptides mass fingerprinting identification, binding, and blocking of inhibitors flavonoids and anthraquinone of


Journal

Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176

Informations de publication

Date de publication:
07 2021
Historique:
pubmed: 23 6 2020
medline: 1 7 2021
entrez: 23 6 2020
Statut: ppublish

Résumé

An rare pandemic of viral pneumonia occurs in December 2019 in Wuhan, China, which is now recognized internationally as Corona Virus Disease 2019 (COVID-19), the etiological agent classified as Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). According to the World Health Organization (WHO), it has so far expanded to more than 213 countries/territories worldwide. Our study aims to find the viral peptides of SARS-COV-2 by peptide mass fingerprinting (PMF) in order to predict its novel structure and find an inhibitor for each viral peptide. For this reason, we calculated the mass of amino acid sequences translated from the SARS-CoV2 whole genome and identify the peptides that may be a target for inhibition. Molecular peptide docking with

Identifiants

pubmed: 32567487
doi: 10.1080/07391102.2020.1778534
pmc: PMC7332867
doi:

Substances chimiques

Anthraquinones 0
Flavonoids 0
Peptides 0
RNA, Viral 0
Hydroxychloroquine 4QWG6N8QKH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4089-4099

Auteurs

Muhammad Hamza (M)

The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Bioinformatics, Govt. Postgraduate College Mandian Abbottabad, Abbottabad, KPK, Pakistan.

Ashaq Ali (A)

Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, China.

Suliman Khan (S)

The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Saeed Ahmed (S)

Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.

Zarlish Attique (Z)

Department of Bioinformatics, Govt. Postgraduate College Mandian Abbottabad, Abbottabad, KPK, Pakistan.

Saad Ur Rehman (S)

Department of Bioinformatics, Govt. Postgraduate College Mandian Abbottabad, Abbottabad, KPK, Pakistan.

Ayesha Khan (A)

Department of Biotechnology, COMSATS Abbottabad, Abbottabad, KPK, Pakistan.

Hussain Ali (H)

Department of Bioinformatics, Govt. Postgraduate College Mandian Abbottabad, Abbottabad, KPK, Pakistan.

Muhammad Rizwan (M)

Department of Bioinformatics, Govt. Postgraduate College Mandian Abbottabad, Abbottabad, KPK, Pakistan.

Anum Munir (A)

Department of Bioinformatics, Govt. Postgraduate College Mandian Abbottabad, Abbottabad, KPK, Pakistan.

Arshad Mehmood Khan (AM)

Department of Chemistry, Govt. Postgraduate College Mandian Abbottabad, Abbottabad, KPK, Pakistan.

Faiza Siddique (F)

Department of Bioinformatics, Govt. Postgraduate College Mandian Abbottabad, Abbottabad, KPK, Pakistan.

Azhar Mehmood (A)

Department of Bioinformatics, Govt. Postgraduate College Mandian Abbottabad, Abbottabad, KPK, Pakistan.

Faisal Nouroz (F)

Department of Bioinformatic, Hazara University Mansehra, Mansehra, KPK, Pakistan.

Sajid Khan (S)

Department of Bioinformatics, Govt. Postgraduate College Mandian Abbottabad, Abbottabad, KPK, Pakistan.

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Classifications MeSH