Enantioselective LC-MS/MS method for the determination of cloperastine enantiomers in rat plasma and its pharmacokinetic application.
LC-MS/MS
antitussive drug
cloperastine
enantioseparation
pharmacokinetics
Journal
Chirality
ISSN: 1520-636X
Titre abrégé: Chirality
Pays: United States
ID NLM: 8914261
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
02
03
2020
revised:
28
04
2020
accepted:
02
06
2020
pubmed:
23
6
2020
medline:
21
5
2021
entrez:
23
6
2020
Statut:
ppublish
Résumé
Cloperastine is a central antitussive used to reduce the frequency and intensity of coughing on a short-term basis. In this study, a reliable chiral LC-MS/MS technology has been developed for the quantification of cloperastine enantiomers in the rat plasma. Carbinoxamine was selected as the internal standard. The enantioseparation of cloperastine was performed on a Chiralpak IA column with a mobile phase composed of acetonitrile-water-ammonium hydroxide (80:20:0.1, v/v/v) at a flow rate of 0.6 mL/min. Cloperastine enantiomers were detected by mass spectrometry in multiple reaction monitoring mode with a positive electrospray ionization source. The method was validated over the linear concentration range of 0.05 to 10.0 ng/mL (5.0 × 10
Substances chimiques
Piperidines
0
cloperastine
69M5L7BXEK
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1129-1138Informations de copyright
© 2020 Wiley Periodicals LLC.
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