A Prospective Validation of the Updated Movement Disorders Society Research Criteria for Prodromal Parkinson's Disease.
Parkinson's disease
cohort
prodromal Parkinson's disease
research criteria
Journal
Movement disorders : official journal of the Movement Disorder Society
ISSN: 1531-8257
Titre abrégé: Mov Disord
Pays: United States
ID NLM: 8610688
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
26
01
2020
revised:
24
04
2020
accepted:
13
05
2020
pubmed:
23
6
2020
medline:
28
4
2021
entrez:
23
6
2020
Statut:
ppublish
Résumé
The objective of this study was to validate the recently updated research criteria for prodromal Parkinson's disease (pPD) proposed by the International Parkinson's Disease and Movement Disorders Society. A total of 16 of 21 markers of pPD were ascertained in the Hellenic Longitudinal Investigation of Aging and Diet cohort composed of community-dwelling individuals aged ≥65 years. The probability of pPD was calculated for 961 individuals without Parkinson's disease (PD) or dementia with Lewy bodies at baseline who were followed-up for a median of 3 years. The ability of the criteria to predict conversion to PD/dementia with Lewy bodies was assessed by estimating their sensitivity and specificity, plotting receiver operating characteristics curves, and using logistic regression. These analyses were repeated using the original criteria. No incident PD/dementia with Lewy bodies case had probable pPD at baseline (ie, ≥80% pPD probability). At cut-offs of 10%, 30%, and 50% probability of pPD, the sensitivity and specificity of the criteria ranged from 4.5% to 27.3%, and 85.7% to 98.3% respectively. The area under the receiver operating characteristics curve was 0.691 (95% confidence intervals, 0.605-0.777). In logistic regression models, the criteria-derived posttest odds of pPD were a significant predictor of conversion at follow-up. The updated criteria performed similarly to the original but showed a slight increase in sensitivity. The new criteria demonstrated suboptimal sensitivity in our random sample of community-dwelling individuals. The absence of specialized assessments with high likelihood ratios in our cohort could be hindering the demonstration of higher sensitivities. Such assessments should be a part of future validation attempts. © 2020 International Parkinson and Movement Disorder Society.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1802-1809Informations de copyright
© 2020 International Parkinson and Movement Disorder Society.
Références
Obeso JA, Stamelou M, Goetz CG, et al. Past, present, and future of Parkinson's disease: a special essay on the 200th Anniversary of the Shaking Palsy. Mov Disord 2017;32:1264-1310.
Postuma RB, Berg D. Prodromal Parkinson's disease: the decade past, the decade to come. Mov Disord 2019;34:665-675.
Obeso JA. Editor's note: prodromal Parkinson's disease. Mov Disord 2019;34:664-664.
Berg D, Postuma RB, Adler CH, et al. MDS research criteria for prodromal Parkinson's disease. Mov Disord 2015;30:1600-1611.
Fereshtehnejad SM, Montplaisir JY, Pelletier A, Gagnon JF, Berg D, Postuma RB. Validation of the MDS research criteria for prodromal Parkinson's disease: longitudinal assessment in a REM sleep behavior disorder (RBD) cohort. Mov Disord 2017;32:865-873.
Mahlknecht P, Gasperi A, Djamshidian A, et al. Performance of the Movement Disorders Society criteria for prodromal Parkinson's disease: a population-based 10-year study. Mov Disord 2018;33:405-413.
Mirelman A, Saunders-Pullman R, Alcalay RN, et al. Application of the Movement Disorder Society prodromal criteria in healthy G2019S-LRRK2 carriers. Mov Disord 2018;33:966-973.
Pilotto A, Heinzel S, Suenkel U, et al. Application of the movement disorder society prodromal Parkinson's disease research criteria in 2 independent prospective cohorts. Mov Disord 2017;32:1025-1034.
Heinzel S, Kasten M, Behnke S, et al. Age- and sex-related heterogeneity in prodromal Parkinson's disease. Mov Disord 2018;33:1025-1027.
Heinzel S, Berg D, Gasser T, et al. Update of the MDS research criteria for prodromal Parkinson's disease. Mov Disord 2019;34:1464-1470.
Dardiotis E, Kosmidis MH, Yannakoulia M, Hadjigeorgiou GM, Scarmeas N. The hellenic longitudinal investigation of aging and diet (HELIAD): rationale, study design, and cohort description. Neuroepidemiology 2014;43:9-14.
Maraki MI, Yannakoulia M, Stamelou M, et al. Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease. Mov Disord 2018;34:48-57.
Maraki MI, Stefanis L, Yannakoulia M, et al. Motor function and the probability of prodromal Parkinson's disease in older adults. Mov Disord 2019;34:1345-1353.
Fahn S, Elton RL, UPDRS Program Members I. Unified Parkinson's disease rating scale. In: Fahn S, Marsden CD, Goldstein M, Calne DB, editors. Recent Developments in Parkinson's Disease. Vol 2. Florham Park, NJ: Macmillan Healthcare Information; 1987:153-163.
Anastasiou CA, Yannakoulia M, Kosmidis MH, et al. Mediterranean diet and cognitive health: initial results from the Hellenic Longitudinal Investigation of Ageing and Diet. Feart C, editor. PLoS ONE 2017;12:e0182048.
Fountoulakis KN, Tsolaki M, Iacovides A, et al. The validation of the short form of the geriatric depression scale (GDS) in Greece. Aging (Milano) 1999;11:367-372.
Michopoulos I, Douzenis A, Kalkavoura C, et al. Hospital Anxiety and Depression Scale (HADS): validation in a Greek general hospital sample. Ann Gen Psychiatry 2008;7:4.
Hays RD, Martin SA, Sesti AM, Spritzer KL. Psychometric properties of the Medical Outcomes Study Sleep measure. Sleep Med 2005;6:41-44.
Cummings JL. The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology 1997;48:10S-16S.
Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 1968;114:797-811.
Kokouva M, Bitsolas N, Hadjigeorgiou GM, Rachiotis G, Papadoulis N, Hadjichristodoulou C. Pesticide exposure and lymphohaematopoietic cancers: a case-control study in an agricultural region (Larissa, Thessaly, Greece). BMC Public Health 2011;11:5.
Buchman AS, Boyle PA, Wilson RS, Fleischman DA, Leurgans S, Bennett DA. Association between late-life social activity and motor decline in older adults. Arch Intern Med 2009;169:1139.
Mamalaki E, Anastasiou CA, Kosmidis MH, et al. Social life characteristics in relation to adherence to the Mediterranean diet in older adults: findings from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD) study. Public Health Nutr 2020;23(3):439-445.
Bountziouka V, Bathrellou E, Giotopoulou A, et al. Development, repeatability and validity regarding energy and macronutrient intake of a semi-quantitative food frequency questionnaire: methodological considerations. Nutr Metab Cardiovasc Dis 2012;22:659-667.
McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology 2005;65:1863-1872.
Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord 2015;30:1591-1601.
Bougea A, Maraki MI, Yannakoulia M, et al. Higher probability of prodromal Parkinson disease is related to lower cognitive performance. Neurology 2019;92:e2261-e2272.
Weintraub D, Chahine LM, Hawkins KA, et al. Cognition and the course of prodromal Parkinson's disease. Mov Disord 2017;32:1640-1645.
Darweesh SKL, Wolters FJ, Postuma RB, et al. Association between poor cognitive functioning and risk of incident parkinsonism. JAMA Neurol 2017;74:1431.
Berg D, Postuma RB, Bloem B, et al. Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease. Mov Disord 2014;29:454-462.
Berg D, Behnke S, Seppi K, et al. Enlarged hyperechogenic substantia nigra as a risk marker for Parkinson's disease. Mov Disord 2013;28:216-219.
Ross GW, Petrovitch H, Abbott RD, et al. Association of olfactory dysfunction with risk for future Parkinson's disease. Ann Neurol 2008;63:167-173.
Postuma RB, Iranzo A, Hu M, et al. Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. Brain 2019;142:744-759.
Pagano G, Ferrara N, Brooks DJ, Pavese N. Age at onset and Parkinson disease phenotype. Neurology 2016;86:1400-1407.
Heinzel S, Roeben B, Ben-Shlomo Y, et al. Prodromal markers in Parkinson's disease: limitations in longitudinal studies and lessons learned. Front Aging Neurosci 2016;8:1-10.