Bioshell calcium oxide (BiSCaO) for cleansing and healing Pseudomonas aeruginosa-infected wounds in hairless rats.
Animal Shells
/ chemistry
Animals
Anti-Bacterial Agents
/ isolation & purification
Bacterial Load
/ drug effects
Calcium Compounds
/ isolation & purification
Disease Models, Animal
Disinfection
/ methods
Male
Mice
Microbial Sensitivity Tests
Oxides
/ isolation & purification
Povidone-Iodine
/ pharmacology
Pseudomonas Infections
/ drug therapy
Pseudomonas aeruginosa
/ drug effects
Rats
Rats, Hairless
Staphylococcal Skin Infections
/ drug therapy
Therapeutic Irrigation
/ methods
Wound Healing
/ drug effects
Bioshell calcium oxide (BiSCaO)
hypochlorous acid
infected wound
microbicidal activity
wound repair
Journal
Bio-medical materials and engineering
ISSN: 1878-3619
Titre abrégé: Biomed Mater Eng
Pays: Netherlands
ID NLM: 9104021
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
12
5
2021
Statut:
ppublish
Résumé
Scallop shell powder is called bioshell calcium oxide (BiSCaO), which is known to possess deodorizing properties and broad antimicrobial activity against various pathogenic microbes, including viruses, bacteria, spores, and fungi. This study aims to investigate the applications of BiSCaO suspension cleansing in clinical situations, for instance for the prevention and treatment of infections in chronic wounds in healing-impaired patients, without delaying wound healing. The bactericidal activities of 1000 ppm BiSCaO suspension; 500 ppm hypochlorous acid; 1000 ppm povidone iodine; and saline were compared to evaluate in vivo disinfection and healing of Pseudomonas aeruginosa-infected wounds in hairless rats. Cleansing of the infected wounds with BiSCaO suspension daily for 3 days significantly enhanced wound healing and reduced the in vivo bacterial counts, in comparison to hypochlorous acid, povidone iodine, and saline. Furthermore, histological examinations showed significantly advanced granulation tissue and capillary formation in the wounds cleansed with BiSCaO suspension than in those cleansed with the other solutions. This study suggested that the possibility of using BiSCaO suspension as a disinfectant for infected wounds and limiting disinfection to 3 days may be sufficient to avoid the negative effects on wound repair.
Sections du résumé
BACKGROUND
BACKGROUND
Scallop shell powder is called bioshell calcium oxide (BiSCaO), which is known to possess deodorizing properties and broad antimicrobial activity against various pathogenic microbes, including viruses, bacteria, spores, and fungi.
OBJECTIVE
OBJECTIVE
This study aims to investigate the applications of BiSCaO suspension cleansing in clinical situations, for instance for the prevention and treatment of infections in chronic wounds in healing-impaired patients, without delaying wound healing.
METHODS
METHODS
The bactericidal activities of 1000 ppm BiSCaO suspension; 500 ppm hypochlorous acid; 1000 ppm povidone iodine; and saline were compared to evaluate in vivo disinfection and healing of Pseudomonas aeruginosa-infected wounds in hairless rats.
RESULTS
RESULTS
Cleansing of the infected wounds with BiSCaO suspension daily for 3 days significantly enhanced wound healing and reduced the in vivo bacterial counts, in comparison to hypochlorous acid, povidone iodine, and saline. Furthermore, histological examinations showed significantly advanced granulation tissue and capillary formation in the wounds cleansed with BiSCaO suspension than in those cleansed with the other solutions.
CONCLUSIONS
CONCLUSIONS
This study suggested that the possibility of using BiSCaO suspension as a disinfectant for infected wounds and limiting disinfection to 3 days may be sufficient to avoid the negative effects on wound repair.
Identifiants
pubmed: 32568170
pii: BME201082
doi: 10.3233/BME-201082
doi:
Substances chimiques
Anti-Bacterial Agents
0
Calcium Compounds
0
Oxides
0
Povidone-Iodine
85H0HZU99M
lime
C7X2M0VVNH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM