Transport of Ca
Animals
Biological Transport
Calcium
/ metabolism
Gene Expression Regulation
Male
Mice
Mice, Inbred C57BL
Mitochondria, Heart
/ metabolism
Mitochondrial Membrane Transport Proteins
/ chemistry
Mitochondrial Permeability Transition Pore
Muscular Dystrophy, Duchenne
/ metabolism
Myocardium
/ pathology
Permeability
Protein Conformation
Sodium-Calcium Exchanger
/ metabolism
Ca(2+) uniporter
Duchenne muscular dystrophy
Heart
Mitochondria
Mitochondrial permeability transition
NCLX
Journal
Biochimica et biophysica acta. Bioenergetics
ISSN: 1879-2650
Titre abrégé: Biochim Biophys Acta Bioenerg
Pays: Netherlands
ID NLM: 101731706
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
17
04
2020
revised:
05
06
2020
accepted:
12
06
2020
pubmed:
23
6
2020
medline:
27
10
2020
entrez:
23
6
2020
Statut:
ppublish
Résumé
Duchenne muscular dystrophy (DMD) is a progressive skeletal muscle disease that is associated with severe cardiac complications in the late stages. Significant mitochondrial dysfunction is reportedly responsible for the development of cardiomyopathy with age. At the same time, adaptive changes in mitochondrial metabolism in cardiomyocytes were identified in the early stages of DMD. In this work, we evaluate the functioning of calcium transport systems (MCU and NCLX), and MPT pore in the heart mitochondria of young dystrophin-deficient mice. As compared to wild-type animals, heart mitochondria of mdx mice have been found to be more efficient both in respect to Ca
Identifiants
pubmed: 32569663
pii: S0005-2728(20)30100-6
doi: 10.1016/j.bbabio.2020.148250
pii:
doi:
Substances chimiques
Mitochondrial Membrane Transport Proteins
0
Mitochondrial Permeability Transition Pore
0
Slc8b1protein, mouse
0
Sodium-Calcium Exchanger
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
148250Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.