Cellular senescence in age-related disorders.
Journal
Translational research : the journal of laboratory and clinical medicine
ISSN: 1878-1810
Titre abrégé: Transl Res
Pays: United States
ID NLM: 101280339
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
17
12
2019
revised:
15
06
2020
accepted:
16
06
2020
pubmed:
23
6
2020
medline:
9
2
2021
entrez:
23
6
2020
Statut:
ppublish
Résumé
Much of the population is now faced with an enormous burden of age-associated chronic diseases. Recent discoveries in geroscience indicate that healthspan in model organisms such as mice can be manipulated by targeting cellular senescence, a hallmark mechanism of aging, defined as an irreversible proliferative arrest that occurs when cells experience oncogenic or other diverse forms of damage. Senescent cells and their proinflammatory secretome have emerged as contributors to age-related tissue dysfunction and morbidity. Cellular senescence has causal roles in mediating osteoporosis, frailty, cardiovascular diseases, osteoarthritis, pulmonary fibrosis, renal diseases, neurodegenerative diseases, hepatic steatosis, and metabolic dysfunction. Therapeutically targeting senescent cells in mice can prevent, delay, or alleviate each of these conditions. Therefore, senotherapeutic approaches, including senolytics and senomorphics, that either selectively eliminate senescent cells or interfere with their ability to promote tissue dysfunction, are gaining momentum as potential realistic strategies to abrogate human senescence to thereby compress morbidity and extend healthspan.
Identifiants
pubmed: 32569840
pii: S1931-5244(20)30146-8
doi: 10.1016/j.trsl.2020.06.007
pmc: PMC7572662
mid: NIHMS1605554
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
96-104Subventions
Organisme : NIAMS NIH HHS
ID : K01 AR070241
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG062413
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK128552
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG065868
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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