Wnt modulation in bone healing.

Animals Bone Regeneration Fracture Healing Fractures, Bone Stem Cells / metabolism Wnt Signaling Pathway beta Catenin / metabolism
BMP Bone DKK1 Fracture healing Glycogen synthase kinase 3β PTH SOST Sclerostin Wnt signaling β-catenin

Journal

Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048

Informations de publication

Date de publication:
09 2020
Historique:
received: 30 04 2020
revised: 09 06 2020
accepted: 11 06 2020
pubmed: 23 6 2020
medline: 22 6 2021
entrez: 23 6 2020
Statut: ppublish

Résumé

Genetic studies have been instrumental in the field of orthopaedics for finding tools to improve the standard management of fractures and delayed unions. The Wnt signaling pathway that is crucial for development and maintenance of many organs also has a very promising pathway for enhancement of bone regeneration. The Wnt pathway has been shown to have a direct effect on stem cells during bone regeneration, making Wnt a potential target to stimulate bone repair after trauma. A more complete view of how Wnt influences animal bone regeneration has slowly come to light. This review article provides an overview of studies done investigating the modulation of the canonical Wnt pathway in animal bone regeneration models. This not only includes a summary of the recent work done elucidating the roles of Wnt and β-catenin in fracture healing, but also the results of thirty transgenic studies, and thirty-eight pharmacological studies. Finally, we discuss the discontinuation of sclerostin clinical trials, ongoing clinical trials with lithium, the results of Dkk antibody clinical trials, the shift into combination therapies and the future opportunities to enhance bone repair and regeneration through the modulation of the Wnt signaling pathway.

Identifiants

DOI: 10.1016/j.bone.2020.115491 PMID: 32569871
pubmed: 32569871
pii: S8756-3282(20)30271-4
doi: 10.1016/j.bone.2020.115491
pii:
doi:

Substances chimiques

beta Catenin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

115491

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Drew Schupbach (D)

Department of Surgery, Division of Orthopedic Surgery, McGill University, Montreal General Hospital, 1650 Cedar Avenue, Room A10-110, Montreal, Québec H3G 1A4, Canada; Experimental Surgery, Faculty of Medicine, McGill University, Montreal General Hospital, 1650 Cedar Avenue, Room A7-117, Montreal, Québec H3G 1A4, Canada. Electronic address: drew.schupbach@mail.mcgill.ca.

Marianne Comeau-Gauthier (M)

Department of Surgery, Division of Orthopedic Surgery, McGill University, Montreal General Hospital, 1650 Cedar Avenue, Room A10-110, Montreal, Québec H3G 1A4, Canada; Experimental Surgery, Faculty of Medicine, McGill University, Montreal General Hospital, 1650 Cedar Avenue, Room A7-117, Montreal, Québec H3G 1A4, Canada. Electronic address: marianne.comeau-gauthier@mail.mcgill.ca.

Edward Harvey (E)

Department of Surgery, Division of Orthopedic Surgery, McGill University, Montreal General Hospital, 1650 Cedar Avenue, Room A10-110, Montreal, Québec H3G 1A4, Canada. Electronic address: edward.harvey@mcgill.ca.

Geraldine Merle (G)

Department of Surgery, Division of Orthopedic Surgery, McGill University, Montreal General Hospital, 1650 Cedar Avenue, Room A10-110, Montreal, Québec H3G 1A4, Canada; Department of Chemical Engineering, Polytechnique Montreal, 2500, chemin de Polytechnique, Montréal, Québec H3T 1J4, Canada. Electronic address: geraldine.merle@polymtl.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Wnt modulation in bone healing.
questionsmedicales.fr › Phénomènes biologiques › Régénération › Remodelage osseux › Régénération osseuse › Wnt modulation in bone healing.
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cicatrisation de plaie › Consolidation de fracture › Wnt modulation in bone healing.
questionsmedicales.fr › Plaies et blessures › Fractures osseuses › Wnt modulation in bone healing.
questionsmedicales.fr › Cellules › Cellules souches › Wnt modulation in bone healing.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › Wnt modulation in bone healing.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › bêta-Caténine › Wnt modulation in bone healing.