Nuclear receptors in osteoclasts.
Journal
Current opinion in pharmacology
ISSN: 1471-4973
Titre abrégé: Curr Opin Pharmacol
Pays: England
ID NLM: 100966133
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
28
11
2019
revised:
09
03
2020
accepted:
23
03
2020
pubmed:
23
6
2020
medline:
12
10
2021
entrez:
23
6
2020
Statut:
ppublish
Résumé
Osteoclasts are bone-resorbing cells that play an essential role in the remodeling of bone under physiological conditions and numerous pathological conditions, such as osteoporosis, bone metastasis, and inflammatory bone erosion. Nuclear receptors are crucial to various physiological processes, including metabolism, development and inflammation, and function as transcription factors to activate target genes. Synthetic ligands of nuclear receptors are also available for the treatment of metabolic and inflammatory diseases. However, dysregulated bone phenotypes have been documented in patients who take synthetic nuclear receptor ligands as a therapy. Therefore, the effect of nuclear receptors on bone cells has become an important area of exploration; additionally, the molecular mechanisms underlying the action of nuclear receptors in osteoclasts have not been completely understood. Here, we cover the recent progress in our understanding of the roles of nuclear receptors in osteoclasts.
Identifiants
pubmed: 32569976
pii: S1471-4892(20)30005-9
doi: 10.1016/j.coph.2020.03.002
pmc: PMC7669703
mid: NIHMS1582487
pii:
doi:
Substances chimiques
Receptors, Cytoplasmic and Nuclear
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
8-17Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR069562
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073156
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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