Lactobacillus rhamnosus GG and HbA1c in middle age and older adults without type 2 diabetes mellitus: A preliminary randomized study.
Diabetes mellitus
Gut microbiota
Lactobacillus
Probiotic
Journal
Diabetes & metabolic syndrome
ISSN: 1878-0334
Titre abrégé: Diabetes Metab Syndr
Pays: Netherlands
ID NLM: 101462250
Informations de publication
Date de publication:
Historique:
received:
05
11
2019
revised:
19
05
2020
accepted:
21
05
2020
pubmed:
23
6
2020
medline:
10
7
2021
entrez:
23
6
2020
Statut:
ppublish
Résumé
Probiotic supplementation improves glycemic control in persons with diabetes and the current study examined whether these benefits extend to healthy individuals. The current study was a 90-day placebo-controlled, double-blind, randomized clinical trial of Lactobacillus rhamnosus GG in healthy middle-aged and older adults. Fasting blood glucose and HbA1c were quantified at baseline and follow up. ANCOVA controlling for baseline values showed group differences in follow up HbA1c [F (1,90) = 8.44, p = 0.005]; HbA1c values increased in the placebo group, though remained stable in the probiotic group. If replicated, Lactobacillus rhamnosus GG may protect against changes in glycemic control.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
Probiotic supplementation improves glycemic control in persons with diabetes and the current study examined whether these benefits extend to healthy individuals.
METHODS
METHODS
The current study was a 90-day placebo-controlled, double-blind, randomized clinical trial of Lactobacillus rhamnosus GG in healthy middle-aged and older adults. Fasting blood glucose and HbA1c were quantified at baseline and follow up.
RESULTS
RESULTS
ANCOVA controlling for baseline values showed group differences in follow up HbA1c [F (1,90) = 8.44, p = 0.005]; HbA1c values increased in the placebo group, though remained stable in the probiotic group.
CONCLUSIONS
CONCLUSIONS
If replicated, Lactobacillus rhamnosus GG may protect against changes in glycemic control.
Identifiants
pubmed: 32570015
pii: S1871-4021(20)30153-3
doi: 10.1016/j.dsx.2020.05.034
pii:
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Glycated Hemoglobin A
0
hemoglobin A1c protein, human
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
907-909Informations de copyright
Published by Elsevier Ltd.