Characterizing the heterogeneous metabolic progression in idiopathic REM sleep behavior disorder.

Aged Brain / metabolism Cross-Sectional Studies Disease Progression Female Humans Image Processing, Computer-Assisted / methods Longitudinal Studies Male Middle Aged Neuroimaging / methods Parkinson Disease / metabolism Positron-Emission Tomography / methods Prodromal Symptoms Sleep Wake Disorders / metabolism
Conversion FDG PET Parkinson’s disease REM sleep behavior disorder

Journal

NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070

Informations de publication

Date de publication:
2020
Historique:
received: 21 09 2019
revised: 10 05 2020
accepted: 11 05 2020
pubmed: 23 6 2020
medline: 30 3 2021
entrez: 23 6 2020
Statut: ppublish

Résumé

Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of synucleinopathies such as Parkinson's disease (PD). Positron emission tomography (PET) with 19 iRBD patients, 38 PD patients and 19 HC subjects underwent PD patients exhibited more extensive relative hyper- and hypo-metabolism than iRBD patients. We identified three dynamic metabolic trajectories, cross-sectional hypo- or hypermetabolism, cross-sectionally unchanged hypo- or hypermetabolism, cross-sectionally late hypo- or hypermetabolism, appearing only in the contrast of PD with iRBD. No correlation was found between relative Cerebral metabolism changes heterogeneously in a continuum extending from HC to iRBD and PD groups in this preliminary study. The distinctive metabolic trajectories point towards a potential neuroimaging biomarker for conversion of iRBD to frank PD, which should be amenable to advanced pattern recognition analysis in future longitudinal studies.

Identifiants

DOI: 10.1016/j.nicl.2020.102294 PMID: 32570206 PMC: PMC7322340
pubmed: 32570206
pii: S2213-1582(20)30131-5
doi: 10.1016/j.nicl.2020.102294
pmc: PMC7322340
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102294

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

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Auteurs

Xianhua Han (X)

PET Center, Huashan Hospital, Fudan University, Shanghai, China.

Ping Wu (P)

PET Center, Huashan Hospital, Fudan University, Shanghai, China.

Ian Alberts (I)

Department of Nuclear Medicine, University of Bern, Switzerland.

Hucheng Zhou (H)

Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication ,Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China.

Huan Yu (H)

Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.

Panagiotis Bargiotas (P)

Department of Neurology, University Hospital Bern (Inselspital) and University of Bern, Bern, Switzerland; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.

Igor Yakushev (I)

Department of Nuclear Medicine, Technische Universität München, Munich, Germany.

Jian Wang (J)

Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.

Guenter Höglinger (G)

Department of Neurology, Hannover Medical School, Germany.

Stefan Förster (S)

Department of Nuclear Medicine, Technische Universität München, Munich, Germany; Department of Nuclear Medicine, Klinikum Bayreuth, Germany.

Claudio Bassetti (C)

Department of Neurology, University Hospital Bern (Inselspital) and University of Bern, Bern, Switzerland.

Wolfgang Oertel (W)

Department of Neurology, University of Marburg, Germany.

Markus Schwaiger (M)

Klinikum r. d. Isar, Technische Universität München, Munich, Germany.

Sung-Cheng Huang (SC)

Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, USA.

Paul Cumming (P)

Department of Nuclear Medicine, University of Bern, Switzerland; School of Psychology and Counselling and IHBI, Queensland University of Technology, Brisbane, Australia.

Axel Rominger (A)

Department of Nuclear Medicine, University of Bern, Switzerland.

Jiehui Jiang (J)

Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication ,Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China. Electronic address: jiangjiehui@shu.edu.cn.

Chuantao Zuo (C)

PET Center, Huashan Hospital, Fudan University, Shanghai, China; Human Phenome Institute, Fudan University, Shanghai, China; Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China. Electronic address: zuochuantao@fudan.edu.cn.

Kuangyu Shi (K)

Department of Nuclear Medicine, University of Bern, Switzerland; Dept. Informatics, Technische Universität München, Munich, Germany.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Characterizing the heterogeneous metabolic...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Characterizing the heterogeneous metabolic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Characterizing the heterogeneous metabolic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Characterizing the heterogeneous metabolic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Characterizing the heterogeneous metabolic...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Traitement d'image par ordinateur › Characterizing the heterogeneous metabolic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Characterizing the heterogeneous metabolic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Characterizing the heterogeneous metabolic...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Characterizing the heterogeneous metabolic...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Characterizing the heterogeneous metabolic...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Characterizing the heterogeneous metabolic...
questionsmedicales.fr › Diagnostic › Symptômes prodromiques › Characterizing the heterogeneous metabolic...
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Characterizing the heterogeneous metabolic...