Can CYP Inhibition Overcome Chemotherapy Resistance?

Cytochrome P-450 Enzyme System Drug Resistance, Neoplasm Humans
anticancer drug resistance cytochrome P450 enzyme induction hepatocellular carcinoma

Journal

Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158

Informations de publication

Date de publication:
08 2020
Historique:
received: 31 05 2020
accepted: 31 05 2020
pubmed: 24 6 2020
medline: 1 9 2021
entrez: 24 6 2020
Statut: ppublish

Résumé

A 2016 study proposed induction of the cytochrome P450 (CYP) enzyme CYP3A5 as a key mechanism for chemotherapy resistance and suggested CYP3A5 as a promising therapeutic target. However, in the context of the available literature we are skeptical that CYP3A5 contributes significantly to cancer drug resistance.

Identifiants

DOI: 10.1016/j.tips.2020.05.007 PMID: 32571525
pubmed: 32571525
pii: S0165-6147(20)30136-X
doi: 10.1016/j.tips.2020.05.007
pii:
doi:

Substances chimiques

Cytochrome P-450 Enzyme System 9035-51-2

Types de publication

Letter Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

503-506

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Magnus Ingelman-Sundberg (M)

Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

Volker M Lauschke (VM)

Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address: volker.lauschke@ki.se.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Can CYP Inhibition Overcome Chemotherapy Resistance?
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Can CYP Inhibition Overcome Chemotherapy Resistance?
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Can CYP Inhibition Overcome Chemotherapy Resistance?