Epitope-based sieve analysis of Plasmodium falciparum sequences from a FMP2.1/AS02

Antibodies, Protozoan Antigens, Protozoan / genetics Epitopes / genetics Humans Malaria Vaccines Malaria, Falciparum / prevention & control Membrane Proteins / genetics Plasmodium falciparum / genetics Protozoan Proteins / genetics
Epitope-specific efficacy FMP2.1/AS02A vaccine Malaria Rational vaccine design Sieve analysis

Journal

Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899

Informations de publication

Date de publication:
31 07 2020
Historique:
received: 03 06 2019
revised: 28 05 2020
accepted: 12 06 2020
pubmed: 24 6 2020
medline: 28 4 2021
entrez: 24 6 2020
Statut: ppublish

Résumé

To prevent premature dismissal of promising vaccine programs, it is critical to determine if lack of efficacy in the field is due to allele specific-efficacy, rather than to the lack of immunogenicity of the candidate antigen. Here we use samples collected during a field trial of the AMA1-based FMP2.1/AS02

Identifiants

DOI: 10.1016/j.vaccine.2020.06.035 PMID: 32571720 PMC: PMC7375901
pubmed: 32571720
pii: S0264-410X(20)30821-5
doi: 10.1016/j.vaccine.2020.06.035
pmc: PMC7375901
mid: NIHMS1604387
pii:
doi:

Substances chimiques

Antibodies, Protozoan 0
Antigens, Protozoan 0
Epitopes 0
Malaria Vaccines 0
Membrane Proteins 0
Protozoan Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

5700-5706

Subventions

Organisme : NIAID NIH HHS
ID : N01AI85346
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI110820
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI114996
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI141900
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW001589
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL140285
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI065683
Pays : United States

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Amed Ouattara (A)

Malaria Research Program, Center for Vaccine Development and Global Heath, University of Maryland School of Medicine, 685 West Baltimore Street HSF1-480 Baltimore, MD 21201, USA; Malaria Research and Training Center, University of Sciences, Techniques and Technology, BP 1805, Bamako, Mali. Electronic address: amouattara@som.umaryland.edu.

Amadou Niangaly (A)

Malaria Research and Training Center, University of Sciences, Techniques and Technology, BP 1805, Bamako, Mali. Electronic address: niangaly@icermali.org.

Matthew Adams (M)

Malaria Research Program, Center for Vaccine Development and Global Heath, University of Maryland School of Medicine, 685 West Baltimore Street HSF1-480 Baltimore, MD 21201, USA. Electronic address: madams@som.umaryland.edu.

Drissa Coulibaly (D)

Malaria Research and Training Center, University of Sciences, Techniques and Technology, BP 1805, Bamako, Mali. Electronic address: drissa@icermali.org.

Abdoulaye K Kone (AK)

Malaria Research and Training Center, University of Sciences, Techniques and Technology, BP 1805, Bamako, Mali. Electronic address: fankone@icermali.org.

Karim Traore (K)

Malaria Research and Training Center, University of Sciences, Techniques and Technology, BP 1805, Bamako, Mali. Electronic address: karim@icermali.org.

Matthew B Laurens (MB)

Malaria Research Program, Center for Vaccine Development and Global Heath, University of Maryland School of Medicine, 685 West Baltimore Street HSF1-480 Baltimore, MD 21201, USA. Electronic address: mlaurens@som.umaryland.edu.

Youssouf Tolo (Y)

Malaria Research and Training Center, University of Sciences, Techniques and Technology, BP 1805, Bamako, Mali. Electronic address: babatolo@yahoo.fr.

Bourema Kouriba (B)

Malaria Research and Training Center, University of Sciences, Techniques and Technology, BP 1805, Bamako, Mali. Electronic address: kouriba@icermali.org.

Dapa A Diallo (DA)

Malaria Research and Training Center, University of Sciences, Techniques and Technology, BP 1805, Bamako, Mali. Electronic address: da.diallo@laposte.net.

Ogobara K Doumbo (OK)

Malaria Research and Training Center, University of Sciences, Techniques and Technology, BP 1805, Bamako, Mali. Electronic address: okd@icermali.org.

Christopher V Plowe (CV)

Duke Global Health Institute, Duke University, NC 27708, USA. Electronic address: cplowe@som.umaryland.edu.

Abdoulaye Djimdé (A)

Malaria Research and Training Center, University of Sciences, Techniques and Technology, BP 1805, Bamako, Mali. Electronic address: adjimde@icermali.org.

Mahamadou A Thera (MA)

Malaria Research and Training Center, University of Sciences, Techniques and Technology, BP 1805, Bamako, Mali. Electronic address: mthera@icermali.org.

Miriam K Laufer (MK)

Malaria Research Program, Center for Vaccine Development and Global Heath, University of Maryland School of Medicine, 685 West Baltimore Street HSF1-480 Baltimore, MD 21201, USA. Electronic address: mlaufer@som.umaryland.edu.

Shannon Takala-Harrison (S)

Malaria Research Program, Center for Vaccine Development and Global Heath, University of Maryland School of Medicine, 685 West Baltimore Street HSF1-480 Baltimore, MD 21201, USA. Electronic address: stakala@som.umaryland.edu.

Joana C Silva (JC)

Institute for Genome Sciences, University of Maryland School of Medicine, 670 West Baltimore St, Baltimore, MD 21201, USA; Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, USA. Electronic address: jcsilva@som.umaryland.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiprotozoaires › Epitope-based sieve analysis of Plasmodium...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de protozoaire › Epitope-based sieve analysis of Plasmodium...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Epitope-based sieve analysis of Plasmodium...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epitope-based sieve analysis of Plasmodium...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiprotozoaires › Vaccins contre le paludisme › Epitope-based sieve analysis of Plasmodium...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Paludisme à Plasmodium falciparum › Epitope-based sieve analysis of Plasmodium...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Epitope-based sieve analysis of Plasmodium...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Epitope-based sieve analysis of Plasmodium...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de protozoaire › Epitope-based sieve analysis of Plasmodium...