Association of the methylene-tetrahydrofolate reductase gene rs1801133 C677T variant with serum homocysteine levels, and the severity of coronary artery disease.
Adult
Aged
Case-Control Studies
Coronary Artery Disease
/ blood
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Homocysteine
/ blood
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
/ genetics
Middle Aged
Polymorphism, Single Nucleotide
ROC Curve
Severity of Illness Index
Tunisia
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 06 2020
22 06 2020
Historique:
received:
25
10
2019
accepted:
29
05
2020
entrez:
24
6
2020
pubmed:
24
6
2020
medline:
15
12
2020
Statut:
epublish
Résumé
This study aimed to investigate whether the single nucleotide polymorphism C677T (rs1801133) of the methylene-tetrahydrofolate reductase (MTHFR) gene was associated with the risk of coronary artery disease (CAD) and circulating homocysteine (Hcy) levels in Tunisian population. 310 angiografically diagnosed CAD patients and 210 controls were enrolled in this study. The MTHFR C677T (rs1801133) polymorphism was genotyped, and the Hcy concentrations were measured. The severity of CAD was evaluated using the Gensini scoring system. Compared to the CC genotype, the TT genotype confers a higher risk for CAD severity with an OR = 9.07 and 95% CI = 3.78-21.8. The T allele was the predisposing allele for CAD and that it was probably associated with CAD severity. The area under the ROC curve for Hcy was 0.764 (95% CI 0.660 to 0.868, p = 0.001). The receiver operating characteristics curve (ROC) for Hcy showed its useful prediction of CAD. Hcy levels were not significantly associated with CAD severity expressed by Gensini Score (GS). The MTHFR C677T (rs1801133) polymorphism influences circulating Hcy levels. The MTHFR C677T polymorphism and hyperhomocysteinemia could have an important role in the prediction of the presence and not the severity expressed by GS of CAD.
Identifiants
pubmed: 32572074
doi: 10.1038/s41598-020-66937-3
pii: 10.1038/s41598-020-66937-3
pmc: PMC7308346
doi:
Substances chimiques
Homocysteine
0LVT1QZ0BA
MTHFR protein, human
EC 1.5.1.20
Methylenetetrahydrofolate Reductase (NADPH2)
EC 1.5.1.20
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10064Références
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