Factors associated with immunosenescence during early adulthood in HIV-infected patients after durable efficient combination antiretroviral therapy.
Antiretroviral Therapy, Highly Active
/ methods
Bone Marrow
/ immunology
CD4-Positive T-Lymphocytes
/ metabolism
Cross-Sectional Studies
Female
HIV Infections
/ drug therapy
Humans
Immunosenescence
Male
Pregnancy
Prenatal Exposure Delayed Effects
/ immunology
Receptors, Antigen, T-Cell
/ metabolism
Telomere Shortening
Thymus Gland
/ immunology
Virus Replication
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 06 2020
22 06 2020
Historique:
received:
09
02
2020
accepted:
02
06
2020
entrez:
24
6
2020
pubmed:
24
6
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Perinatally HIV-infected patients face the consequences of both chronic infection effects per se and long-term combination antiretroviral therapy (cART) on immunosenescence. Aims of our study were to evaluate which factors independently contribute to immunosenescence in HIV-infected young adults with a very different HIV infection duration (perinatally HIV-infected young individuals -pHIVy- and age-matched non perinatally HIV-infected youths -npHIVy), after durable efficient cART. We considered low thymic and bone marrow output, respectively evaluated by quantifying T-cell receptor excision circles (TRECs), K-deleting recombination excision circles (KRECs), and shorter telomeres lenght (TL) as surrogate biomarkers of immunosenescence. Twenty-one pHIVy and 19 npHIVy (with a mean HIV duration of 3-8 years) were included; mean age was 27 years for both groups. Immunosenescence biomarkers were comparable between pHIVy and npHIVy (despite longer HIV-infection, higher frequency of AIDS events, past cART-free periods and concomitant chronic viral infections in pHIVy). At the multivariate analysis, CD4+ was the only variable independently associated with TRECs and TL. Our data suggest that a good level of thymic activity can compensate the deleterious effects of past periods without cART, if HIV replication is suppressed for a sufficient time.
Identifiants
pubmed: 32572110
doi: 10.1038/s41598-020-67100-8
pii: 10.1038/s41598-020-67100-8
pmc: PMC7308364
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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