Mucosal-associated invariant T (MAIT) cells provide B-cell help in vaccinated and subsequently SIV-infected Rhesus Macaques.
Animals
B-Lymphocytes
/ metabolism
Bronchoalveolar Lavage Fluid
/ immunology
Female
Interferon-gamma
/ metabolism
Ki-67 Antigen
/ metabolism
Longitudinal Studies
Lymphocyte Activation
Macaca mulatta
Mucosal-Associated Invariant T Cells
/ metabolism
Simian Acquired Immunodeficiency Syndrome
/ immunology
Simian Immunodeficiency Virus
/ immunology
Tumor Necrosis Factor-alpha
/ metabolism
Vaccination
/ veterinary
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 06 2020
22 06 2020
Historique:
received:
03
02
2020
accepted:
26
05
2020
entrez:
24
6
2020
pubmed:
24
6
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Mucosal-associated invariant T (MAIT) cells help combat opportunistic infections. Thus, MAIT cells are of interest in HIV/SIV vaccination and infection. We investigated MAIT cell dynamics and function in rhesus macaque blood and bronchoalveolar lavage (BAL) following mucosal adenovirus (Ad)-SIV recombinant priming, intramuscular SIV envelope boosting and infection following repeated low-dose intravaginal SIV exposures. Increased frequencies of blood MAIT cells over the course of vaccination were observed, which were maintained even 12-weeks post-SIV infection. BAL MAIT cells only increased after the first Ad immunization. Vaccination increased MAIT cell levels in blood and BAL expressing the antiviral cytokine IFN-γ and TNF-α and the proliferation marker Ki67. Upon T cell-specific α-CD3, α-CD28 stimulation, MAIT cells showed a greater capacity to secrete cytokines/chemokines associated with help for B cell activation, migration and regulation compared to CD3
Identifiants
pubmed: 32572140
doi: 10.1038/s41598-020-66964-0
pii: 10.1038/s41598-020-66964-0
pmc: PMC7308357
doi:
Substances chimiques
Ki-67 Antigen
0
Tumor Necrosis Factor-alpha
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
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