Endogenous calcitonin gene-related peptide in cerebrospinal fluid and early quality of life and mental health after good-grade spontaneous subarachnoid hemorrhage-a feasibility series.
Adult
Aged
Biomarkers
/ cerebrospinal fluid
Blood Vessel Prosthesis Implantation
/ psychology
Calcitonin Gene-Related Peptide
/ cerebrospinal fluid
Cohort Studies
Endovascular Procedures
/ psychology
Feasibility Studies
Female
Humans
Male
Mental Health
/ trends
Middle Aged
Pilot Projects
Prospective Studies
Quality of Life
/ psychology
Subarachnoid Hemorrhage
/ cerebrospinal fluid
Vasodilator Agents
/ cerebrospinal fluid
CGRP
Calcitonin gene-related peptide
Health-related quality of life
Impairment
Neuropsychological outcome
Spontaneous subarachnoid hemorrhage
Journal
Neurosurgical review
ISSN: 1437-2320
Titre abrégé: Neurosurg Rev
Pays: Germany
ID NLM: 7908181
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
23
12
2019
accepted:
05
06
2020
revised:
22
04
2020
pubmed:
24
6
2020
medline:
14
7
2021
entrez:
24
6
2020
Statut:
ppublish
Résumé
The vasodilatory calcitonin gene-related peptide (CGRP) is excessively released after spontaneous subarachnoid hemorrhage (sSAH) and modulates psycho-behavioral function. In this pilot study, we prospectively analyzed the treatment-specific differences in the secretion of endogenous CGRP into cerebrospinal fluid (CSF) during the acute stage after good-grade sSAH and its impact on self-reported health-related quality of life (hrQoL). Twenty-six consecutive patients (f:m = 13:8; mean age 50.6 years) with good-grade sSAH were enrolled (drop out 19% (n = 5)): 35% (n = 9) underwent endovascular aneurysm occlusion, 23% (n = 6) microsurgery, and 23% (n = 6) of the patients with perimesencephalic SAH received standardized intensive medical care. An external ventricular drain was inserted within 72 h after the onset of bleeding. CSF was drawn daily from day 1-10. CGRP levels were determined via competitive enzyme immunoassay and calculated as "area under the curve" (AUC). All patients underwent a hrQoL self-report assessment (36-Item Short Form Health Survey (SF-36), ICD-10-Symptom-Rating questionnaire (ISR)) after the onset of sSAH (t
Identifiants
pubmed: 32572710
doi: 10.1007/s10143-020-01333-z
pii: 10.1007/s10143-020-01333-z
pmc: PMC8121729
doi:
Substances chimiques
Biomarkers
0
Vasodilator Agents
0
Calcitonin Gene-Related Peptide
JHB2QIZ69Z
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1479-1492Références
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