Retinal vessel oximetry in children with inherited retinal diseases.
children
cone-rod dystrophy
inherited macular dystrophy
inherited retinal diseases
oxygen saturation
retinal vessel diameter
retinal vessel oximetry
rod-cone dystrophy
screening
Journal
Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
11
12
2019
accepted:
21
04
2020
pubmed:
24
6
2020
medline:
7
9
2021
entrez:
24
6
2020
Statut:
ppublish
Résumé
Retinal vessel oximetry (RO) has been used to show altered metabolic function in patients with inherited retinal diseases (IRDs). The aim of this study was to investigate RO parameters of children with IRDs and presumed IRD carriers (pIRDc) and to compare them to controls. In this cross-sectional cohort study, 142 eyes from 71 Caucasian subjects were included: 40 eyes with IRDs, 26 eyes with pIRDc and 76 control eyes. The oxygen saturation was measured with the Retinal Vessel Analyser (IMEDOS Systems UG, Jena, Germany). Mean oxygen saturations in the peripapillary retinal arterioles (A-SO In general, children suffering from IRDs differed from controls when the A-SO In general, we found that children with IRDs presented early metabolic changes. Within IRDs, children with RCD showed more affected metabolic changes. Thus, RO may support early screening to rule out IRDs in children, and more precisely may help to differentiate those suffering from RCD.
Sections du résumé
BACKGROUND
BACKGROUND
Retinal vessel oximetry (RO) has been used to show altered metabolic function in patients with inherited retinal diseases (IRDs). The aim of this study was to investigate RO parameters of children with IRDs and presumed IRD carriers (pIRDc) and to compare them to controls.
METHODS
METHODS
In this cross-sectional cohort study, 142 eyes from 71 Caucasian subjects were included: 40 eyes with IRDs, 26 eyes with pIRDc and 76 control eyes. The oxygen saturation was measured with the Retinal Vessel Analyser (IMEDOS Systems UG, Jena, Germany). Mean oxygen saturations in the peripapillary retinal arterioles (A-SO
RESULTS
RESULTS
In general, children suffering from IRDs differed from controls when the A-SO
CONCLUSION
CONCLUSIONS
In general, we found that children with IRDs presented early metabolic changes. Within IRDs, children with RCD showed more affected metabolic changes. Thus, RO may support early screening to rule out IRDs in children, and more precisely may help to differentiate those suffering from RCD.
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
52-60Subventions
Organisme : Liechtenstein Stiftung
Organisme : Gottfried und Julia Bangerter-Rhyner-Stiftung
ID : YTCR11/2017
Organisme : Schweizerische Akademie der Medizinischen Wissenschaften
ID : YTCR11/2017
Organisme : Stiftung Ostschweizerische Pleoptik- and Orthoptik-Schule
Informations de copyright
© 2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
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