Polo-like kinase 1 (Plk1) is a positive regulator of DNA replication in the
Animals
Blastula
/ metabolism
Cell Cycle Proteins
/ metabolism
Chromatin
/ metabolism
Cyclin-Dependent Kinase 2
/ metabolism
DNA Replication
Multiprotein Complexes
/ metabolism
Phosphorylation
Phosphoserine
/ metabolism
Phosphothreonine
/ metabolism
Protein Phosphatase 2
/ metabolism
Protein Serine-Threonine Kinases
/ metabolism
Proto-Oncogene Proteins
/ metabolism
S Phase
Stress, Physiological
Xenopus laevis
/ metabolism
Polo-Like Kinase 1
Xenopus
DNA replication
Polo-like kinase 1 (Plk1)
checkpoint
Journal
Cell cycle (Georgetown, Tex.)
ISSN: 1551-4005
Titre abrégé: Cell Cycle
Pays: United States
ID NLM: 101137841
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
pubmed:
24
6
2020
medline:
3
9
2021
entrez:
24
6
2020
Statut:
ppublish
Résumé
Polo-like kinase 1 (Plk1) is a cell cycle kinase essential for mitosis progression, but also important for checkpoint recovery and adaptation in response to DNA damage and replication stress. However, although Plk1 is expressed in S phase, little is known about its function during unperturbed DNA replication. Using
Identifiants
pubmed: 32573322
doi: 10.1080/15384101.2020.1782589
pmc: PMC7469467
doi:
Substances chimiques
Cell Cycle Proteins
0
Chromatin
0
Multiprotein Complexes
0
Proto-Oncogene Proteins
0
Phosphothreonine
1114-81-4
Phosphoserine
17885-08-4
Protein Serine-Threonine Kinases
EC 2.7.11.1
Cyclin-Dependent Kinase 2
EC 2.7.11.22
Protein Phosphatase 2
EC 3.1.3.16
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1817-1832Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
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