Maternal approach behaviors toward neonatal calls are impaired by mother's experiences of raising pups with a risk gene variant for autism.
22q11
ASD
CNV
Tbx1
USV
maternal behaviors
mouse
Journal
Developmental psychobiology
ISSN: 1098-2302
Titre abrégé: Dev Psychobiol
Pays: United States
ID NLM: 0164074
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
27
01
2020
revised:
07
04
2020
accepted:
01
06
2020
pubmed:
24
6
2020
medline:
15
12
2021
entrez:
24
6
2020
Statut:
ppublish
Résumé
How the intrinsic sequence structure of neonatal mouse pup ultrasonic vocalization (USV) and maternal experiences determine maternal behaviors in mice is poorly understood. Our previous work showed that pups with a Tbx1 heterozygous (HT) mutation, a genetic risk for autism spectrum disorder (ASD), emit altered call sequences that do not induce maternal approach behaviors in C57BL6/J mothers. Here, we tested how maternal approach behaviors induced by wild-type and HT USVs are influenced by the mother's experience in raising pups of these two genotypes. The results showed that wild-type USVs were effective in inducing maternal approach behaviors when mothers raised wild-type but not HT pups. The USVs of HT pups were ineffective regardless of whether mothers raised HT or wild-type pups. However, the sequence structure of pup USVs had no effect on the general, non-directional incentive motivation of maternal behaviors. Our data show how the mother's experience with a pup with a genetic risk for ASD alters the intrinsic incentive values of USV sequences in maternal approach behaviors.
Identifiants
pubmed: 32573780
doi: 10.1002/dev.22006
pmc: PMC7755688
mid: NIHMS1615913
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108-113Subventions
Organisme : Japan Society for the Promotion of Science
ID : 18H04890
Organisme : Japan Society for the Promotion of Science
ID : 19K22373
Organisme : Japan Society for the Promotion of Science
ID : 19K21822
Organisme : NIDCD NIH HHS
ID : R01 DC015776
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH099660
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
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