Role of Terlipressin and Albumin for Hepatorenal Syndrome in Liver Transplantation.
Journal
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
ISSN: 1527-6473
Titre abrégé: Liver Transpl
Pays: United States
ID NLM: 100909185
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
09
03
2020
revised:
25
05
2020
accepted:
16
06
2020
pubmed:
24
6
2020
medline:
19
3
2021
entrez:
24
6
2020
Statut:
ppublish
Résumé
Hepatorenal syndrome (HRS) is one of the most ominous complications of portal hypertension in patients with decompensated cirrhosis and ascites. It is associated with very high mortality on the wait list. Liver transplantation (LT) is the most successful therapeutic option for patients with HRS. However, not all the LT candidates with HRS are able to receive a deceased donor allograft in a timely manner because it is a scarce resource and patients may need alternative best supportive treatment with systemic splanchnic vasoconstrictors and albumin as a bridge to transplant. The combination of terlipressin and albumin is efficacious in the reversal of HRS and is used worldwide. More recently, the multicenter, randomized, placebo-controlled double-blind study to confirm efficacy and safety of terlipressin in subjects with hepatorenal syndrome type 1 (the CONFIRM study) trial demonstrated the efficacy of terlipressin and albumin in the reversal of HRS in a North American cohort. The aim of this article is to review the role of terlipressin and albumin in LT candidates with HRS in the United States.
Substances chimiques
Albumins
0
Vasoconstrictor Agents
0
Lypressin
50-57-7
Terlipressin
7Z5X49W53P
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1328-1336Informations de copyright
Copyright © 2020 by the American Association for the Study of Liver Diseases.
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