Viral delivery of multiple miRNAs promotes retinal ganglion cell survival and functional preservation after optic nerve crush injury.

Animals Cell Survival Cells, Cultured Disease Models, Animal Electroretinography Female MicroRNAs / genetics Nerve Regeneration Optic Nerve / metabolism Optic Nerve Injuries / metabolism Rats Rats, Sprague-Dawley Retinal Ganglion Cells / metabolism
Adeno-associated virus Exosomes Neuroprotection Optic nerve crush PTEN Retinal ganglion cells miRNA

Journal

Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707

Informations de publication

Date de publication:
08 2020
Historique:
received: 20 01 2019
revised: 12 05 2020
accepted: 13 05 2020
pubmed: 24 6 2020
medline: 14 1 2021
entrez: 24 6 2020
Statut: ppublish

Résumé

Bone marrow mesenchymal stem cell (BMSC)-derived small extracellular vesicles (sEV) but not fibroblast sEV provide retinal ganglion cell (RGC) neuroprotection both in vitro and in vivo, with miRNAs playing an essential role. More than 40 miRNAs were more abundant in BMSC-sEV than in fibroblast-sEV. The purpose of this study was to test the in vitro and in vivo neuroprotective and axogenic properties of six candidate miRNAs (miR-26a, miR-17, miR-30c-2, miR-92a, miR-292, and miR-182) that were more abundant in BMSC-sEV than in fibroblast-sEV. Adeno-associated virus 2 (AAV2) expressing a combination of three of the above candidate miRNAs were added to heterogenous adult rat retinal cultures or intravitreally injected into rat eyes one week before optic nerve crush (ONC) injury. Survival and neuritogenesis of βIII-tubulin

Identifiants

DOI: 10.1016/j.exer.2020.108071 PMID: 32574667 PMC: PMC7484142
pubmed: 32574667
pii: S0014-4835(20)30330-4
doi: 10.1016/j.exer.2020.108071
pmc: PMC7484142
mid: NIHMS1609137
pii:
doi:

Substances chimiques

MicroRNAs 0

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108071

Subventions

Organisme : Intramural NIH HHS
ID : Z01 EY000318
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 EY999999
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA EY000318
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Ben Mead (B)

School of Optometry and Vision Sciences, Cardiff University, Cardiff, CF24 4HQ, UK; Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: MeadB@Cardiff.ac.uk.

Erin Cullather (E)

Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Naoki Nakaya (N)

Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Yuzhe Niu (Y)

Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Christo Kole (C)

Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Zubair Ahmed (Z)

Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK.

Stanislav Tomarev (S)

Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: tomarevs@nei.nih.gov.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Viral delivery of multiple miRNAs promotes...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Viral delivery of multiple miRNAs promotes...
questionsmedicales.fr › Cellules › Cellules cultivées › Viral delivery of multiple miRNAs promotes...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Viral delivery of multiple miRNAs promotes...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Électrodiagnostic › Électrorétinographie › Viral delivery of multiple miRNAs promotes...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Viral delivery of multiple miRNAs promotes...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Régénération nerveuse › Viral delivery of multiple miRNAs promotes...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs crâniens › Nerf optique › Viral delivery of multiple miRNAs promotes...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions traumatiques des nerfs crâniens › Lésions traumatiques du nerf optique › Viral delivery of multiple miRNAs promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Viral delivery of multiple miRNAs promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Viral delivery of multiple miRNAs promotes...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Neurones rétiniens › Cellules ganglionnaires rétiniennes › Viral delivery of multiple miRNAs promotes...