Do 1,8-naphthyridine sulfonamides possess an inhibitory action against Tet(K) and MsrA efflux pumps in multiresistant Staphylococcus aureus strains?

Anti-Bacterial Agents / pharmacology Bacterial Proteins / genetics Ethidium Microbial Sensitivity Tests Naphthyridines / pharmacology Staphylococcus aureus Sulfonamides / pharmacology
Antibacterial agent Bacterial resistance Efflux pump Ethidium bromide Synergism

Journal

Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191

Informations de publication

Date de publication:
Oct 2020
Historique:
received: 02 01 2020
accepted: 14 05 2020
pubmed: 24 6 2020
medline: 22 6 2021
entrez: 24 6 2020
Statut: ppublish

Résumé

Naphthyridines represent a class of heterocyclic compounds formed by two condensed aromatic rings. This study aimed to evaluate the antibacterial activity and in vitro inhibition of efflux resistance mechanisms of a series of 1,8-naphthyridine sulfonamides against strains carrying Tet(K) and MsrA efflux pumps. The efflux pump inhibitory capacity was evaluated by analyzing synergistic effects between 1,8-naphthyridine sulfonamides and standard antibiotics, as well as ethidium bromide. The following 1,8-naphthyridines were used: 4-methyl-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 1); 2,5-Dichloro-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 2); 2,3,4-trifluoro-N-(5-chloro-1,8-naphthyridin-2-yl)benzenesulfonamide (Naph 7); 3-trifluoromethyl-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 9). The 1,8-naphthyridine sulfonamide derivatives possessed a potential Tet(K) and MsrA efflux pump inhibitory action.

Identifiants

DOI: 10.1016/j.micpath.2020.104268 PMID: 32574783
pubmed: 32574783
pii: S0882-4010(20)30634-3
doi: 10.1016/j.micpath.2020.104268
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Bacterial Proteins 0
Naphthyridines 0
Sulfonamides 0
Ethidium EN464416SI

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104268

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Cícera Datiane de Morais Oliveira-Tintino (CDM)

Laboratory of Pharmatoxicological Prospecting of Bioactive Products, Department of Antibiotics, Federal University of Pernambuco, UFPE, Recife, PE, Brazil. Electronic address: datianemorais@hotmail.com.

Saulo Relison Tintino (SR)

Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil.

Débora Feitosa Muniz (DF)

Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil.

Cristina Rodrigues Dos Santos Barbosa (CRDS)

Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil.

Raimundo Luiz Silva Pereira (RLS)

Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil.

Iêda Maria Begnini (IM)

Department of Chemistry, Regional University of Blumenau, FURB, Itoupava Seca, 89030-903, Blumenau, SC, Brazil.

Ricardo Andrade Rebelo (RA)

Department of Chemistry, Regional University of Blumenau, FURB, Itoupava Seca, 89030-903, Blumenau, SC, Brazil.

Luiz Everson da Silva (LE)

Postgraduate Program in Sustainable Territorial Development, Coastal Sector, Federal University of Paraná, Curitiba, PR, Brazil.

Sandro Lucio Mireski (SL)

Department of Chemistry, Regional University of Blumenau, FURB, Itoupava Seca, 89030-903, Blumenau, SC, Brazil.

Michele Caroline Nasato (MC)

Department of Chemistry, Regional University of Blumenau, FURB, Itoupava Seca, 89030-903, Blumenau, SC, Brazil.

Maria Isabel Lacowicz Krautler (MI)

Department of Chemistry, Regional University of Blumenau, FURB, Itoupava Seca, 89030-903, Blumenau, SC, Brazil.

Pedro Silvino Pereira (PS)

Laboratory of Pharmatoxicological Prospecting of Bioactive Products, Department of Antibiotics, Federal University of Pernambuco, UFPE, Recife, PE, Brazil.

Alexandre Magno Rodrigues Teixeira (AMR)

Laboratory of Simulations and Molecular Spectroscopy, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil.

Irwin Rose Alencar de Menezes (IRA)

Laboratory of Pharmacology and Molecular Chemistry, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil.

Henrique Douglas Melo Coutinho (HDM)

Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, URCA, Crato, CE, Brazil.

Teresinha Gonçalves da Silva (TGD)

Laboratory of Pharmatoxicological Prospecting of Bioactive Products, Department of Antibiotics, Federal University of Pernambuco, UFPE, Recife, PE, Brazil.

Articles similaires

Vancomycin-associated DRESS demonstrates delay in AST abnormalities.

Ahmed Hussein, Kateri L Schoettinger, Jourdan Hydol-Smith et al.
1.00
Humans Drug Hypersensitivity Syndrome Vancomycin Female Male

Atomic view of photosynthetic metabolite permeability pathways and confinement in synthetic carboxysome shells.

Daipayan Sarkar, Christopher Maffeo, Markus Sutter et al.
1.00
Photosynthesis Ribulose-Bisphosphate Carboxylase Carbon Dioxide Molecular Dynamics Simulation Cyanobacteria

Management of the infected total elbow arthroplasty.

Joaquin Sanchez-Sotelo
1.00
Humans Arthroplasty, Replacement, Elbow Prosthesis-Related Infections Debridement Anti-Bacterial Agents

Mathematical modeling of vancomycin release from Poly-L-Lactic Acid-Coated implants.

Papon Thamvasupong, Kwanchanok Viravaidya-Pasuwat
1.00
Vancomycin Polyesters Anti-Bacterial Agents Models, Theoretical Drug Liberation

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Do 1,8-naphthyridine sulfonamides possess an...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Do 1,8-naphthyridine sulfonamides possess an...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Phénanthridines › Éthidium › Do 1,8-naphthyridine sulfonamides possess an...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Do 1,8-naphthyridine sulfonamides possess an...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Naphtyridines › Do 1,8-naphthyridine sulfonamides possess an...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Do 1,8-naphthyridine sulfonamides possess an...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Do 1,8-naphthyridine sulfonamides possess an...