Altered large-scale organization of shape processing in visual agnosia.
Object recognition
Two visual pathways
Visual agnosia
fMRI
Journal
Cortex; a journal devoted to the study of the nervous system and behavior
ISSN: 1973-8102
Titre abrégé: Cortex
Pays: Italy
ID NLM: 0100725
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
11
11
2019
revised:
29
02
2020
accepted:
04
05
2020
pubmed:
24
6
2020
medline:
22
6
2021
entrez:
24
6
2020
Statut:
ppublish
Résumé
Recent findings suggest that both dorsal and ventral visual pathways process shape information. Nevertheless, a lesion to the ventral pathway alone can result in visual agnosia, an impairment in shape perception. Here, we explored the neural basis of shape processing in a patient with visual agnosia following a circumscribed right hemisphere ventral lesion and evaluated longitudinal changes in the neural profile of shape representations. The results revealed a reduction of shape sensitivity slopes along the patient's right ventral pathway and a similar reduction in the contralesional left ventral pathway. Remarkably, posterior parts of the dorsal pathway bilaterally also evinced a reduction in shape sensitivity. These findings were similar over a two-year interval, revealing that a focal cortical lesion can lead to persistent large-scale alterations of the two visual pathways. These alterations are consistent with the view that a distributed network of regions contributes to shape perception.
Identifiants
pubmed: 32574843
pii: S0010-9452(20)30198-2
doi: 10.1016/j.cortex.2020.05.009
pmc: PMC9972005
mid: NIHMS1874550
pii:
doi:
Types de publication
Case Reports
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
423-435Subventions
Organisme : NEI NIH HHS
ID : R01 EY026701
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY027018
Pays : United States
Organisme : NEI NIH HHS
ID : R21 EY023067
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing interests.
Références
Nature. 1991 Jan 10;349(6305):154-6
pubmed: 1986306
Cortex. 2018 Jan;98:8-27
pubmed: 27890325
Neuropsychologia. 2010 May;48(6):1828-41
pubmed: 20227431
J Neurosci. 2016 Jan 13;36(2):432-44
pubmed: 26758835
Cereb Cortex. 2019 Jul 5;29(7):3168-3181
pubmed: 30169596
Exp Brain Res. 2003 Nov;153(2):180-9
pubmed: 12961051
Nat Neurosci. 2008 Feb;11(2):224-31
pubmed: 18193041
Cereb Cortex. 2001 Apr;11(4):287-97
pubmed: 11278192
J Exp Psychol Hum Percept Perform. 2003 Feb;29(1):19-42
pubmed: 12669745
Cereb Cortex. 2014 Apr;24(4):1102-18
pubmed: 23250954
Trends Cogn Sci. 2016 Oct;20(10):773-784
pubmed: 27615805
Brain. 1999 Mar;122 ( Pt 3):537-59
pubmed: 10094261
Neuron. 2011 Jul 14;71(1):49-60
pubmed: 21745637
Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):E5214-23
pubmed: 25404310
Brain. 2014 Sep;137(Pt 9):2408-22
pubmed: 24871646
Q J Exp Psychol A. 1984 Aug;36(3):385-415
pubmed: 6533691
Brain Struct Funct. 2018 Jul;223(6):2589-2607
pubmed: 29536173
Nat Commun. 2016 Jul 18;7:12141
pubmed: 27424918
Cortex. 1979 Sep;15(3):403-19
pubmed: 540512
Curr Opin Neurobiol. 2015 Aug;33:141-9
pubmed: 25876179
Trends Cogn Sci. 2013 May;17(5):210-9
pubmed: 23608364
Brain. 2013 Sep;136(Pt 9):2784-98
pubmed: 23983030
Open Mind (Camb). 2020 Aug;4:40-56
pubmed: 33225195
J Cogn Neurosci. 2019 Jun;31(6):821-836
pubmed: 30883289
Cogn Neuropsychol. 2003 Oct 1;20(7):641-71
pubmed: 20957588
J Nerv Ment Dis. 1950 Jan;111(1):41-51
pubmed: 15402617
Cereb Cortex. 2017 Jan 1;27(1):422-434
pubmed: 26483400
J Cogn Neurosci. 2015 May;27(5):1029-43
pubmed: 25390203
Cereb Cortex. 2019 May 1;29(5):2034-2050
pubmed: 29659730
Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8135-9
pubmed: 7667258
Conscious Cogn. 2018 Sep;64:106-120
pubmed: 29779844
Cortex. 1993 Sep;29(3):529-42
pubmed: 8258290
Elife. 2017 Aug 21;6:
pubmed: 28825896
Cortex. 2018 Jan;98:34-48
pubmed: 28431740
Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E361-70
pubmed: 25583504
PLoS Biol. 2016 Apr 15;14(4):e1002445
pubmed: 27082854
J Cogn Neurosci. 2019 Oct;31(10):1589-1597
pubmed: 31180266
Cortex. 1985 Mar;21(1):121-34
pubmed: 3987306
Neuroreport. 2001 Jun 13;12(8):1581-7
pubmed: 11409720
Magn Reson Med. 1995 Oct;34(4):537-41
pubmed: 8524021
Neurocase. 2002;8(6):466-79
pubmed: 12529455
Elife. 2017 Oct 05;6:
pubmed: 28980938
J Cogn Neurosci. 2018 Jul;30(7):1047-1058
pubmed: 29561234
Brain. 1987 Dec;110 ( Pt 6):1431-62
pubmed: 3427396
J Cogn Neurosci. 2013 Jun;25(6):862-71
pubmed: 23410033
Hum Brain Mapp. 1998;6(4):316-28
pubmed: 9704268
Neuropsychology. 2005 May;19(3):318-31
pubmed: 15910118
J Cogn Neurosci. 2001 May 15;13(4):419-29
pubmed: 11388916
J Nucl Med. 1998 Dec;39(12):2044-7
pubmed: 9867139
Brain. 1991 Apr;114 ( Pt 2):789-800
pubmed: 2043949
Nat Neurosci. 2009 Jan;12(1):29-31
pubmed: 19029889