Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study.
Biomonitoring
Breast milk
Human milk
Micronutrients
Premature infant
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
29
04
2020
accepted:
22
05
2020
pubmed:
24
6
2020
medline:
21
11
2020
entrez:
24
6
2020
Statut:
ppublish
Résumé
Concentrated human milk (HM-concentrate) can be obtained from the simple and inexpensive method of donated breast milk direct lyophilization. A previous study reported that HM-concentrate contains the adequate amount of main macro- and micronutrients for use as a nutritional resource for preterm infants with very low birth weight admitted to neonatal intensive care units. However, further details need to be elucidated about HM-concentrate composition, particularly its content of essential and potentially toxic trace elements. Therefore, this study aimed to determine the concentration of essential and toxic elements in human milk considered baseline (HM-baseline) and HM-concentrate, as well as to quantify changes in concentration of these elements after the HM concentration process. The concentration of Aluminum, Arsenic, Cadmium, Chromium, Iron, Mercury, Manganese, Nickel, Lead, Selenium, Tin, and Thallium was analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Moreover, Bayesian linear mixed effect models were applied to estimate the mean difference between HM-baseline and HM-concentrate samples. After comparison (HM-concentrate versus HM-baseline), a significant increase in concentration was observed only for Manganese (0.80 μg/L; 95% CrI [0.16; 1.43]) and Selenium (6.74 μg/L; 95% CrI [4.66; 8.86]), while Lead concentration (-6.13 μg/L; 95% CrI [-8.63; -3.61]) decreased. This study provides latest and reliable information about HM composition. After milk concentration by lyophilization, there was a significant increase only in the essential elements Manganese and Selenium. The essential micronutrient content in HM-concentrate was similar or higher than that in preterm mothers' milk, which suggests it is viable for nutritional support of preterm infants. In addition, the low concentrations of potentially toxic elements in HM-concentrate indicates that it is safe for consumption by premature newborns.
Identifiants
pubmed: 32574850
pii: S0013-9351(20)30626-5
doi: 10.1016/j.envres.2020.109733
pmc: PMC7479503
pii:
doi:
Substances chimiques
Trace Elements
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109733Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Chemosphere. 2011 Sep;85(2):268-76
pubmed: 21696802
Am J Perinatol. 2014 Nov;31(11):993-1002
pubmed: 24683069
Biol Trace Elem Res. 2013 Jan;151(1):30-7
pubmed: 23152002
J Perinatol. 2016 Oct;36(10):897-900
pubmed: 27253894
Environ Int. 2019 Feb;123:224-230
pubmed: 30537637
Nutr Clin Pract. 2015 Feb;30(1):44-58
pubmed: 25527182
J Perinatol. 2016 Mar;36(3):216-20
pubmed: 26562370
Biol Trace Elem Res. 2019 Jan;187(1):32-40
pubmed: 29700700
Neonatology. 2017;112(4):330-336
pubmed: 28768286
Sci Total Environ. 2019 Feb 10;650(Pt 2):3075-3083
pubmed: 30373084
J Pediatr. 2016 Aug;175:100-105.e2
pubmed: 27131403
J Perinatol. 2018 Mar;38(3):197-202
pubmed: 29298985
Nutrients. 2015 Jan 08;7(1):423-42
pubmed: 25580815
Chemosphere. 2018 Jan;191:911-921
pubmed: 29145136
BMC Pediatr. 2012 Aug 17;12:124
pubmed: 22900590
Nutrients. 2017 Mar 18;9(3):
pubmed: 28335478
JPEN J Parenter Enteral Nutr. 2018 May;42(4):813-820
pubmed: 28622483
Nutr Rev. 2019 Dec 1;77(12):865-877
pubmed: 31532494
J Perinatol. 2018 Jan;38(1):71-74
pubmed: 29048409
Front Nutr. 2017 May 26;4:20
pubmed: 28603716
Environ Health Perspect. 2008 Jul;116(7):963-9
pubmed: 18629322
Environ Health Perspect. 2015 May;123(5):500-6
pubmed: 25707031
PLoS One. 2017 Aug 17;12(8):e0183367
pubmed: 28817665
Biol Trace Elem Res. 2014 Jul;160(1):116-22
pubmed: 24881955
Lancet. 2017 Apr 22;389(10079):1660-1668
pubmed: 28443560
Biol Trace Elem Res. 2012 Jun;147(1-3):36-43
pubmed: 22161501
Cochrane Database Syst Rev. 2019 Aug 12;8:CD002972
pubmed: 31452191
Environ Int. 2019 Aug;129:470-477
pubmed: 31158593
J Environ Health Sci Eng. 2018 Oct 25;16(2):323-335
pubmed: 30729003
Lancet Glob Health. 2019 Jan;7(1):e37-e46
pubmed: 30389451
Neurotoxicology. 2017 Jan;58:23-41
pubmed: 27825840
Early Hum Dev. 2013 Oct;89 Suppl 2:S3-6
pubmed: 23932110
Biol Trace Elem Res. 2018 Jul;184(1):7-15
pubmed: 28967039
J Trace Elem Med Biol. 2019 Jul;54:199-205
pubmed: 31109612
Early Hum Dev. 2015 Nov;91(11):629-35
pubmed: 26375355
Biol Trace Elem Res. 2016 Nov;174(1):65-70
pubmed: 27147432
BMC Public Health. 2017 May 25;17(1):505
pubmed: 28545513
Biol Trace Elem Res. 2016 Apr;170(2):279-87
pubmed: 26315304
Ann Glob Health. 2016 Jan-Feb;82(1):119-31
pubmed: 27325070
Int J Hyg Environ Health. 2019 Apr;222(3):563-582
pubmed: 30878540
Food Chem Toxicol. 2015 Jun;80:287-297
pubmed: 25837421
J Trace Elem Med Biol. 2018 Dec;50:8-15
pubmed: 30262320
J Nutr. 2016 Oct;146(10):2067-2074
pubmed: 27558578
Environ Health. 2012 Dec 14;11:92
pubmed: 23241426
Environ Res. 2020 Jan;180:108820
pubmed: 31639654
Int J Anal Chem. 2018 Apr 4;2018:1784073
pubmed: 29849639
PLoS One. 2017 Sep 28;12(9):e0185632
pubmed: 28957424
Chemosphere. 2005 Oct;61(2):238-47
pubmed: 16168747
J Trace Elem Med Biol. 2016 Dec;38:117-125
pubmed: 27522529
Bull Environ Contam Toxicol. 2013 Nov;91(5):549-54
pubmed: 24068462
Nutrients. 2019 Aug 09;11(8):
pubmed: 31405051
Pediatr Neonatol. 2014 Apr;55(2):127-34
pubmed: 24231114
Environ Sci Pollut Res Int. 2019 Mar;26(8):7405-7427
pubmed: 30687894
Nutrients. 2019 May 16;11(5):
pubmed: 31100900
Sci Total Environ. 2017 Feb 1;579:805-813
pubmed: 27866735
Environ Res. 2016 Nov;151:671-688
pubmed: 27619212
Environ Res. 2019 Feb;169:246-255
pubmed: 30476748
PLoS One. 2019 Feb 20;14(2):e0210999
pubmed: 30785913
J Pediatr. 2010 Feb;156(2 Suppl):S3-7
pubmed: 20105662