EBV renders B cells susceptible to HIV-1 in humanized mice.
Animals
B-Lymphocytes
/ metabolism
CD4 Antigens
/ immunology
Coinfection
Disease Models, Animal
Disease Susceptibility
/ metabolism
Epstein-Barr Virus Infections
/ immunology
HIV Infections
/ genetics
HIV Seropositivity
HIV-1
/ metabolism
Hematopoietic Stem Cells
/ pathology
Herpesvirus 4, Human
/ immunology
Humans
Male
Mice
Mice, Inbred NOD
Receptors, CXCR4
/ metabolism
T-Lymphocytes
/ immunology
Journal
Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
06
01
2020
revised:
10
06
2020
accepted:
11
06
2020
entrez:
25
6
2020
pubmed:
25
6
2020
medline:
15
7
2021
Statut:
epublish
Résumé
HIV and EBV are human pathogens that cause a considerable burden to worldwide health. In combination, these viruses are linked to AIDS-associated lymphomas. We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4
Identifiants
pubmed: 32576602
pii: 3/8/e202000640
doi: 10.26508/lsa.202000640
pmc: PMC7335381
pii:
doi:
Substances chimiques
CD4 Antigens
0
CXCR4 protein, human
0
Receptors, CXCR4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020 McHugh et al.
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