Efficient self-assembly of heterometallic triangular necklace with strong antibacterial activity.
Anti-Bacterial Agents
/ chemistry
Bacteria
/ drug effects
Copper
/ chemistry
Crystallography, X-Ray
DNA Cleavage
/ drug effects
Drug Resistance, Bacterial
/ drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Models, Molecular
Molecular Structure
Organometallic Compounds
/ chemistry
Platinum
/ chemistry
Stereoisomerism
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
23 06 2020
23 06 2020
Historique:
received:
25
09
2019
accepted:
21
05
2020
entrez:
25
6
2020
pubmed:
25
6
2020
medline:
28
8
2020
Statut:
epublish
Résumé
Sophisticated mechanically interlocked molecules (MIMs) with interesting structures, properties and applications have attracted great interest in the field of supramolecular chemistry. We herein report a highly efficient self-assembly of heterometallic triangular necklace 1 containing Cu and Pt metals with strong antibacterial activity. Single-crystal X-ray analysis shows that the finely arranged triangular necklace 1 has two racemic enantiomers in its solid state with intriguing packing motif. The superior antibacterial activity of necklace 1 against both standard and clinically drug-resistant pathogens implies that the presence of Cu(I) center and platinum(II) significantly enhance the bacterium-binding/damaging activity, which is mainly attributed to the highly positively charged nature, the possible synergistic effect of heterometals in the necklace, and the improved stability in culture media. This work clearly discloses the structure-property relationships that the existence of two different metal centers not only facilitates successful construction of heterometallic triangular necklace but also endows it with superior nuclease properties and antibacterial activities.
Identifiants
pubmed: 32576814
doi: 10.1038/s41467-020-16940-z
pii: 10.1038/s41467-020-16940-z
pmc: PMC7311404
doi:
Substances chimiques
Anti-Bacterial Agents
0
Organometallic Compounds
0
Platinum
49DFR088MY
Copper
789U1901C5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3178Références
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